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The protease/antiprotease balance determines influenza susceptibility and can be modified by oxidants and antioxidants.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	The protease/antiprotease balance determines influenza susceptibility and can be modified by oxidants and antioxidants.
作者:	Meyer, Megan Garcia.
面頁冊數:	209 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:	Dissertation Abstracts International76-09B(E).
標題:	Immunology.
標題:	Microbiology.
標題:	Nutrition.
ISBN:	9781321759457
摘要、提要註:	The respiratory epithelium functions as a central orchestrator to initiate and organize responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory epithelium and are involved in respiratory homeostasis. Modifications to the protease/antiprotease balance can lead to the development of lung diseases such as emphysema or chronic obstructive pulmonary disease. Furthermore, altered protease/antiprotease balance, in favor for increased protease activity, is associated with increased susceptibility to respiratory viral infections such as influenza virus. We demonstrated that inhaled oxidants, such as cigarette smoke, alters intracellular regulation and extracellular modifications of a key respiratory antiprotease, secretory leukocyte protease inhibitor (SLPI). Additionally, we established that SLPI is a novel anti-influenza biomarker that restricts influenza infection in vivo and in vitro. Furthermore, we investigated the effect of nutritional antioxidants, such as sulforaphane (SFN), on SLPI expression and found that SFN induced SLPI expression and secretion using in vivo and in vitro models. Finally, we detailed that smokers have increased secretions of an influenza-activating protease, transmembrane protease serine 2 (TMPRSS2) and that SFN supplementation reduced TMPRSS2 secretion, which protected against influenza infection in vitro. Taken together, these studies establish the integral role of the respiratory protease/antiprotease balance in the context of an influenza infection and after oxidant/antioxidant exposure. Further, these findings have broad implications for other inhaled oxidants, such as wood smoke and ozone, and offer the use of SFN as possible nutritional therapeutic to boost respiratory mucosal responses and/or protect against influenza infection.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3703871

The protease/antiprotease balance determines influenza susceptibility and can be modified by oxidants and antioxidants.
Meyer, Megan Garcia.

The protease/antiprotease balance determines influenza susceptibility and can be modified by oxidants and antioxidants. - 209 p.

Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2015.

The respiratory epithelium functions as a central orchestrator to initiate and organize responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory epithelium and are involved in respiratory homeostasis. Modifications to the protease/antiprotease balance can lead to the development of lung diseases such as emphysema or chronic obstructive pulmonary disease. Furthermore, altered protease/antiprotease balance, in favor for increased protease activity, is associated with increased susceptibility to respiratory viral infections such as influenza virus. We demonstrated that inhaled oxidants, such as cigarette smoke, alters intracellular regulation and extracellular modifications of a key respiratory antiprotease, secretory leukocyte protease inhibitor (SLPI). Additionally, we established that SLPI is a novel anti-influenza biomarker that restricts influenza infection in vivo and in vitro. Furthermore, we investigated the effect of nutritional antioxidants, such as sulforaphane (SFN), on SLPI expression and found that SFN induced SLPI expression and secretion using in vivo and in vitro models. Finally, we detailed that smokers have increased secretions of an influenza-activating protease, transmembrane protease serine 2 (TMPRSS2) and that SFN supplementation reduced TMPRSS2 secretion, which protected against influenza infection in vitro. Taken together, these studies establish the integral role of the respiratory protease/antiprotease balance in the context of an influenza infection and after oxidant/antioxidant exposure. Further, these findings have broad implications for other inhaled oxidants, such as wood smoke and ozone, and offer the use of SFN as possible nutritional therapeutic to boost respiratory mucosal responses and/or protect against influenza infection.

ISBN: 9781321759457Subjects--Topical Terms:

402223
Immunology.

The protease/antiprotease balance determines influenza susceptibility and can be modified by oxidants and antioxidants.
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