大葉大學圖書館 |

Stereoselective desymmetrization methods in the assembly of complex natural molecules[electronic resource] /

紀錄類型:	書目-電子資源 : Monograph/item
杜威分類號:	547.2
書名/作者:	Stereoselective desymmetrization methods in the assembly of complex natural molecules/ by Robert.J Sharpe.
作者:	Sharpe, Robert.J.
出版者:	Cham : : Springer International Publishing :, 2016.
面頁冊數:	xxix, 266 p. : : ill. (some col.), digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Organic compounds - Synthesis.
標題:	Asymmetry (Chemistry)
標題:	Chemistry.
標題:	Organic Chemistry.
標題:	Medicinal Chemistry.
標題:	Industrial Chemistry/Chemical Engineering.
ISBN:	9783319390253
ISBN:	9783319390246
內容註:	Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor -- Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity -- Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline.
摘要、提要註:	This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials - the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
電子資源:	http://dx.doi.org/10.1007/978-3-319-39025-3

Stereoselective desymmetrization methods in the assembly of complex natural molecules[electronic resource] /
Sharpe, Robert.J.

Stereoselective desymmetrization methods in the assembly of complex natural molecules[electronic resource] /by Robert.J Sharpe. - Cham :Springer International Publishing :2016. - xxix, 266 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor -- Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity -- Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline.

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials - the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.

ISBN: 9783319390253

Standard No.: 10.1007/978-3-319-39025-3doiSubjects--Topical Terms:

403654
Organic compounds
--Synthesis.

LC Class. No.: QD262

Dewey Class. No.: 547.2

Stereoselective desymmetrization methods in the assembly of complex natural molecules[electronic resource] /
LDR:02459nmm a2200325 a 4500 001 458472
003 DE-He213
005 20161117111746.0
006 m d
007 cr nn 008maaau
008 170113s2016 gw s 0 eng d
020 $a 9783319390253 $q (electronic bk.)
020 $a 9783319390246 $q (paper)
024 7 $a 10.1007/978-3-319-39025-3 $2 doi
035 $a 978-3-319-39025-3
040 $a GP $c GP
041 0 $a eng
050 4 $a QD262
072 7 $a PNN $2 bicssc
072 7 $a SCI013040 $2 bisacsh
082 0 4 $a 547.2 $2 23
090 $a QD262 $b .S532 2016
100 1 $a Sharpe, Robert.J. $3 659720
245 1 0 $a Stereoselective desymmetrization methods in the assembly of complex natural molecules $h [electronic resource] / $c by Robert.J Sharpe.
260 $a Cham : $c 2016. $b Springer International Publishing : $b Imprint: Springer,
300 $a xxix, 266 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor -- Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity -- Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline.
520 $a This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials - the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
650 0 $a Organic compounds $x Synthesis. $3 403654
650 0 $a Asymmetry (Chemistry) $3 611091
650 1 4 $a Chemistry. $3 182539
650 2 4 $a Organic Chemistry. $3 464487
650 2 4 $a Medicinal Chemistry. $3 463754
650 2 4 $a Industrial Chemistry/Chemical Engineering. $3 463779
710 2 $a SpringerLink (Online service) $3 463450
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 463746
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-39025-3
950 $a Chemistry and Materials Science (Springer-11644)