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Regulation of Chromosome Dynamics by...

Icahn School of Medicine at Mount Sinai.

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.
作者:	Shah, Nagma.
面頁冊數:	47 p.
附註:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
標題:	Oncology.
標題:	Biology.
ISBN:	9781321990362
摘要、提要註:	Smc5/6 is one of three related complexes that regulate chromosome dynamics. It is closely related to cohesin, which encircles sister chromatids until anaphase. Cohesin is stripped from chromosomes in a two-step process: first, from chromosome arms at prophase by an unknown mechanism; second, centromeric cohesin is cleaved, enabling sister separation. Smc5/6-dysfunction leads to a failure of arm cohesin removal, causing mitotic defects. Loss of H2A.Z causes aneuploidy, reduces arm cohesin levels, and suppresses cohesin retention in Smc5/6 mutants. Canonical H2A with various post-translational modifications occupies regions that normally contain H2A.Z nucleosomes in these cells. I have explored a role of H2A in cohesin regulation, and found that gamma-H2A is critical for Smc5/6 mutants to survive DNA damage, and is increased in the absence of H2A.Z. Thus, the presence of gamma-H2A rather than the absence of H2A.Z may be critical in cohesin regulation, expanding the epigenetic control of the cohesin cycle.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1596932

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.
Shah, Nagma.

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants. - 47 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--Icahn School of Medicine at Mount Sinai, 2015.

Smc5/6 is one of three related complexes that regulate chromosome dynamics. It is closely related to cohesin, which encircles sister chromatids until anaphase. Cohesin is stripped from chromosomes in a two-step process: first, from chromosome arms at prophase by an unknown mechanism; second, centromeric cohesin is cleaved, enabling sister separation. Smc5/6-dysfunction leads to a failure of arm cohesin removal, causing mitotic defects. Loss of H2A.Z causes aneuploidy, reduces arm cohesin levels, and suppresses cohesin retention in Smc5/6 mutants. Canonical H2A with various post-translational modifications occupies regions that normally contain H2A.Z nucleosomes in these cells. I have explored a role of H2A in cohesin regulation, and found that gamma-H2A is critical for Smc5/6 mutants to survive DNA damage, and is increased in the absence of H2A.Z. Thus, the presence of gamma-H2A rather than the absence of H2A.Z may be critical in cohesin regulation, expanding the epigenetic control of the cohesin cycle.

ISBN: 9781321990362Subjects--Topical Terms:

205017
Oncology.

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.
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100 1 $a Shah, Nagma. $3 629890
245 1 0 $a Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.
300 $a 47 p.
500 $a Source: Masters Abstracts International, Volume: 55-01.
500 $a Adviser: Matthew J. O'Connell.
502 $a Thesis (M.S.)--Icahn School of Medicine at Mount Sinai, 2015.
520 $a Smc5/6 is one of three related complexes that regulate chromosome dynamics. It is closely related to cohesin, which encircles sister chromatids until anaphase. Cohesin is stripped from chromosomes in a two-step process: first, from chromosome arms at prophase by an unknown mechanism; second, centromeric cohesin is cleaved, enabling sister separation. Smc5/6-dysfunction leads to a failure of arm cohesin removal, causing mitotic defects. Loss of H2A.Z causes aneuploidy, reduces arm cohesin levels, and suppresses cohesin retention in Smc5/6 mutants. Canonical H2A with various post-translational modifications occupies regions that normally contain H2A.Z nucleosomes in these cells. I have explored a role of H2A in cohesin regulation, and found that gamma-H2A is critical for Smc5/6 mutants to survive DNA damage, and is increased in the absence of H2A.Z. Thus, the presence of gamma-H2A rather than the absence of H2A.Z may be critical in cohesin regulation, expanding the epigenetic control of the cohesin cycle.
590 $a School code: 1734.
650 4 $a Oncology. $3 205017
650 4 $a Biology. $3 171887
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690 $a 0306
710 2 $a Icahn School of Medicine at Mount Sinai. $b Cancer Biology. $3 629891
773 0 $t Masters Abstracts International $g 55-01(E).
790 $a 1734
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1596932

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