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Asymmetric synthesis of bioactive la...

Doran, Robert.

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	547.2
書名/作者:	Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones/ by Robert Doran.
作者:	Doran, Robert.
出版者:	Cham : : Springer International Publishing :, 2015.
面頁冊數:	xxi, 202 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Asymmetric synthesis.
標題:	Biosynthesis.
標題:	Ketones.
標題:	Chemistry.
標題:	Organic Chemistry.
標題:	Catalysis.
標題:	Medicinal Chemistry.
ISBN:	9783319205441 (electronic bk.)
ISBN:	9783319205434 (paper)
摘要、提要註:	This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.
電子資源:	http://dx.doi.org/10.1007/978-3-319-20544-1

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones[electronic resource] /
Doran, Robert.

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones[electronic resource] /by Robert Doran. - Cham :Springer International Publishing :2015. - xxi, 202 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.

ISBN: 9783319205441 (electronic bk.)

Standard No.: 10.1007/978-3-319-20544-1doiSubjects--Topical Terms:

490177
Asymmetric synthesis.

LC Class. No.: QD262

Dewey Class. No.: 547.2

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones[electronic resource] /
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520 $a This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.
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650 0 $a Biosynthesis. $3 588249
650 0 $a Ketones. $3 470490
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650 2 4 $a Organic Chemistry. $3 464487
650 2 4 $a Catalysis. $3 419032
650 2 4 $a Medicinal Chemistry. $3 463754
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