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Genomic instability and cancer metastasis[electronic resource] :mechanisms, emerging themes, and novel therapeutic strategies /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.994
書名/作者:	Genomic instability and cancer metastasis : mechanisms, emerging themes, and novel therapeutic strategies // edited by Chris Maxwell, Cal Roskelley.
其他作者:	Maxwell, Chris.
出版者:	Cham : : Springer International Publishing :, 2015.
面頁冊數:	x, 247 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Metastasis - Genetic aspects.
標題:	Cancer - Genetic aspects.
標題:	Biomedicine.
標題:	Cancer Research.
標題:	Biomedicine general.
標題:	Molecular Medicine.
標題:	Life Sciences, general.
標題:	Cell Biology.
ISBN:	9783319121369 (electronic bk.)
ISBN:	9783319121352 (paper)
內容註:	Preface.-- Cancer Metastasis: Tracking and Attacking a Moving Target.-- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.-- DNA damage response pathways in cancer predisposition and progression.-- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.-- Animal models of metastasis.-- Microenvironmental Control Of Metastatic Progression.-- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine Nanoparticles in Cancer Imaging and Therapy -- Index.
摘要、提要註:	Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.
電子資源:	http://dx.doi.org/10.1007/978-3-319-12136-9

Genomic instability and cancer metastasis[electronic resource] :mechanisms, emerging themes, and novel therapeutic strategies /
Genomic instability and cancer metastasismechanisms, emerging themes, and novel therapeutic strategies /[electronic resource] :edited by Chris Maxwell, Cal Roskelley. - Cham :Springer International Publishing :2015. - x, 247 p. :ill., digital ;24 cm. - Cancer metastasis - biology and treatment,v.201568-2102 ;. - Cancer metastasis - biology and treatment ;v.18..

Preface.-- Cancer Metastasis: Tracking and Attacking a Moving Target.-- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.-- DNA damage response pathways in cancer predisposition and progression.-- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.-- Animal models of metastasis.-- Microenvironmental Control Of Metastatic Progression.-- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine Nanoparticles in Cancer Imaging and Therapy -- Index.

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

ISBN: 9783319121369 (electronic bk.)

Standard No.: 10.1007/978-3-319-12136-9doiSubjects--Topical Terms:

605178
Metastasis
--Genetic aspects.

LC Class. No.: RC269.5

Dewey Class. No.: 616.994

Genomic instability and cancer metastasis[electronic resource] :mechanisms, emerging themes, and novel therapeutic strategies /
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