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Adenoviral vectors for gene therapy[electronic resource] /

纪录类型:	书目-语言数据,印刷品 : Monograph/item
[NT 15000414] null:	616/.042
[NT 47271] Title/Author:	Adenoviral vectors for gene therapy/ edited by David T. Curiel, Joanne T. Douglas.
[NT 51406] other author:	Douglas, Joanne T.
出版者:	Amsterdam ; : Academic Press,, c2002.
面页册数:	1 online resource (xxviii, 677 p.) : : ill.
标题:	Gene therapy.
标题:	Adenoviruses.
标题:	Gene Therapy - methods.
标题:	Adenoviridae.
标题:	Genetic Vectors - therapeutic use.
标题:	Th�erapie g�enique.
标题:	Ad�enovirus.
标题:	HEALTH & FITNESS - Diseases
标题:	MEDICAL - Genetics.
标题:	Adenov�irus.
标题:	Genes virais.
标题:	V�irus de dna.
ISBN:	9780121995041
ISBN:	0121995046
ISBN:	9781435632004 (electronic bk.)
ISBN:	1435632001 (electronic bk.)
[NT 15000227] null:	Includes bibliographical references.
[NT 15000228] null:	Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer.
[NT 15000229] null:	Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials.
电子资源:	http://www.sciencedirect.com/science/book/9780121995041

Adenoviral vectors for gene therapy[electronic resource] /
Adenoviral vectors for gene therapy[electronic resource] /edited by David T. Curiel, Joanne T. Douglas. - Amsterdam ;Academic Press,c2002. - 1 online resource (xxviii, 677 p.) :ill.

Includes bibliographical references.

Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer.

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials.

ISBN: 9780121995041

Source: 89480:89480Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

427973
Gene therapy.
Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: RB155.8 / .A34 2002eb

Dewey Class. No.: 616/.042

National Library of Medicine Call No.: 2002 H-966

Adenoviral vectors for gene therapy[electronic resource] /
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245 0 0 $a Adenoviral vectors for gene therapy $h [electronic resource] / $c edited by David T. Curiel, Joanne T. Douglas.
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300 $a 1 online resource (xxviii, 677 p.) : $b ill.
504 $a Includes bibliographical references.
505 0 $a Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer.
520 $a Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials.
588 $a Description based on print version record.
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650 0 $a Adenoviruses. $3 443061
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650 2 2 $a Adenoviridae. $3 443062
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650 6 $a Th�erapie g�enique. $3 443064
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650 7 $a Adenov�irus. $2 larpcal $3 443066
650 7 $a Genes virais. $2 larpcal $3 443067
650 7 $a V�irus de dna. $2 larpcal $3 443068
655 4 $a Electronic books. $2 local $3 336502
700 1 $a Douglas, Joanne T. $3 443060
700 1 $a Curiel, David. $3 443059
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