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Handbook of epigenetics[electronic resource] :the new molecular and medical genetics /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	572.865
書名/作者:	Handbook of epigenetics : the new molecular and medical genetics // Trygve Tollefsbol.
作者:	Tollefsbol, Trygve O.
出版者:	London : : Academic,, 2010.
面頁冊數:	1 online resource.
標題:	Epigenesis.
標題:	Genetic regulation.
ISBN:	9780123757098
ISBN:	0123757096
內容註:	1. Epigenetics: The New Science of Genetics -- SECTION I: Molecular Mechanisms of Epigenetics -- 2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals -- 3. Mechanisms of Histone Modifications -- SECTION II: Additional Epigenetic Processes -- 4. The Epigenetics of Non-coding RNA -- 5. Prions and Prion-like Phenomena in Epigenetic Inheritance -- 6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies -- 7. Polycomb Mechanisms and Epigenetic Control of Gene Activity -- SECTION III: Epigenetic Technology -- 8. Analysis of Gene-specific DNA Methylation -- 9. Methods for Assessing Genome-wide DNA Methylation -- 10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis -- 11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus -- 12. Assessing Epigenetic Information -- SECTION IV: Model Organisms of Epigenetics -- 13. Epigenetics of Eukaryotic Microbes -- 14. Drosophila Epigenetics -- 15. Mouse Models of Epigenetic Inheritance -- 16. Epigenetic Regulatory Mechanisms in Plants -- SECTION V: Metabolism and Epigenetics -- 17. Metabolic Regulation of DNA Methylation in Mammals -- 18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling -- SECTION VI: Functions of Epigenetics -- 19. Epigenetics, Stem Cells and Cellular Differentiation -- 20. Epigenetic Basis of Skeletal Muscle Regeneration -- 21. Epigenetics of X Chromosome Inactivation -- 22. Genomic Imprinting -- 23. Epigenetics of Memory Processes -- 24. Transgenerational Epigenetics -- 25. Aging Epigenetics -- SECTION VII: Evolutionary Epigenetics -- 26. Epigenetics in Adaptive Evolution and Development -- SECTION VIII: Epigenetic Epidemiology -- 27. The Effects of Diet on Epigenetic Processes -- 28. Environmental Agents and Epigenetics -- 29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis -- 30. DNA Methylation Profiles in the 5'-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome -- 31. Population Pharmacoepigenomics -- SECTION IX: Epigenetics and Human Disease -- 32. Cancer Epigenetics -- 33. The Role of Epigenetics in Immune Disorders -- 34. Epigenetics of Brain Disorders -- 35. Complex Metabolic Syndromes and Epigenetics -- 36. Imprinting Disorders in Humans -- SECTION X: Epigenetic Therapy -- 37. Clinical Applications of Histone Deacetylase Inhibitors.
摘要、提要註:	Epigenetics is considered by many to be the "new genetics" because the realization that many biological phenomena are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes that have opened up new paths for discovery. The biological processes impacted by epigenetics range from tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation to genomic imprinting and aging. The effects of epigenetics are vast and encompass lower organisms as well as humans. Aberrations of epigenetics influence many diseases involving but not limited to cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases. Clinical intervention is already in place for some of these disorders and many novel epigenetic therapies are on the horizon.
電子資源:	An electronic book accessible through the World Wide Web; click for information

Handbook of epigenetics[electronic resource] :the new molecular and medical genetics /
Tollefsbol, Trygve O.

Handbook of epigeneticsthe new molecular and medical genetics /[electronic resource] :Trygve Tollefsbol. - London :Academic,2010. - 1 online resource.

1. Epigenetics: The New Science of Genetics -- SECTION I: Molecular Mechanisms of Epigenetics -- 2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals -- 3. Mechanisms of Histone Modifications -- SECTION II: Additional Epigenetic Processes -- 4. The Epigenetics of Non-coding RNA -- 5. Prions and Prion-like Phenomena in Epigenetic Inheritance -- 6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies -- 7. Polycomb Mechanisms and Epigenetic Control of Gene Activity -- SECTION III: Epigenetic Technology -- 8. Analysis of Gene-specific DNA Methylation -- 9. Methods for Assessing Genome-wide DNA Methylation -- 10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis -- 11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus -- 12. Assessing Epigenetic Information -- SECTION IV: Model Organisms of Epigenetics -- 13. Epigenetics of Eukaryotic Microbes -- 14. Drosophila Epigenetics -- 15. Mouse Models of Epigenetic Inheritance -- 16. Epigenetic Regulatory Mechanisms in Plants -- SECTION V: Metabolism and Epigenetics -- 17. Metabolic Regulation of DNA Methylation in Mammals -- 18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling -- SECTION VI: Functions of Epigenetics -- 19. Epigenetics, Stem Cells and Cellular Differentiation -- 20. Epigenetic Basis of Skeletal Muscle Regeneration -- 21. Epigenetics of X Chromosome Inactivation -- 22. Genomic Imprinting -- 23. Epigenetics of Memory Processes -- 24. Transgenerational Epigenetics -- 25. Aging Epigenetics -- SECTION VII: Evolutionary Epigenetics -- 26. Epigenetics in Adaptive Evolution and Development -- SECTION VIII: Epigenetic Epidemiology -- 27. The Effects of Diet on Epigenetic Processes -- 28. Environmental Agents and Epigenetics -- 29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis -- 30. DNA Methylation Profiles in the 5'-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome -- 31. Population Pharmacoepigenomics -- SECTION IX: Epigenetics and Human Disease -- 32. Cancer Epigenetics -- 33. The Role of Epigenetics in Immune Disorders -- 34. Epigenetics of Brain Disorders -- 35. Complex Metabolic Syndromes and Epigenetics -- 36. Imprinting Disorders in Humans -- SECTION X: Epigenetic Therapy -- 37. Clinical Applications of Histone Deacetylase Inhibitors.

Epigenetics is considered by many to be the "new genetics" because the realization that many biological phenomena are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes that have opened up new paths for discovery. The biological processes impacted by epigenetics range from tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation to genomic imprinting and aging. The effects of epigenetics are vast and encompass lower organisms as well as humans. Aberrations of epigenetics influence many diseases involving but not limited to cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases. Clinical intervention is already in place for some of these disorders and many novel epigenetic therapies are on the horizon.

ISBN: 9780123757098

Source: 1057413:10578001Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

428059
Epigenesis.
Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: QL971 / .T65 2010

Dewey Class. No.: 572.865

Handbook of epigenetics[electronic resource] :the new molecular and medical genetics /
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