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Identifying biomarkers for resistanc...

Hess, Becky Michelle.

Identifying biomarkers for resistance to novel cisplatin analogues in human breast, lung and prostate cancers.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	Identifying biomarkers for resistance to novel cisplatin analogues in human breast, lung and prostate cancers.
作者:	Hess, Becky Michelle.
面頁冊數:	113 p.
附註:	Source: Masters Abstracts International, Volume: 48-02, page: 1046.
Contained By:	Masters Abstracts International48-02.
標題:	Biology, Molecular.
標題:	Chemistry, Biochemistry.
標題:	Health Sciences, Oncology.
ISBN:	9781109476750
摘要、提要註:	Cisplatin is a common therapeutic agent used in cancer treatment. Unfortunately, resistance to cisplatin in addition to severe side effects limits its use in cancer treatment. Two novel cisplatin analogues, 4DB and 4TB were shown to have varying cytotoxicity in lung, breast and prostate cancer cells. The hypothesis for this study states that the differences in 4DB and 4TB cytotoxicity among different tissue types is due to the type and efficiency of DNA repair mechanisms involved in response to these drugs.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1472415

Identifying biomarkers for resistance to novel cisplatin analogues in human breast, lung and prostate cancers.
Hess, Becky Michelle.

Identifying biomarkers for resistance to novel cisplatin analogues in human breast, lung and prostate cancers. - 113 p.

Source: Masters Abstracts International, Volume: 48-02, page: 1046.

Thesis (M.S.)--University of Nevada, Las Vegas, 2009.

Cisplatin is a common therapeutic agent used in cancer treatment. Unfortunately, resistance to cisplatin in addition to severe side effects limits its use in cancer treatment. Two novel cisplatin analogues, 4DB and 4TB were shown to have varying cytotoxicity in lung, breast and prostate cancer cells. The hypothesis for this study states that the differences in 4DB and 4TB cytotoxicity among different tissue types is due to the type and efficiency of DNA repair mechanisms involved in response to these drugs.

ISBN: 9781109476750Subjects--Topical Terms:

422925
Biology, Molecular.

Identifying biomarkers for resistance to novel cisplatin analogues in human breast, lung and prostate cancers.
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020 $a 9781109476750
035 $a (UMI)AAI1472415
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040 $a UMI $c UMI
100 1 $a Hess, Becky Michelle. $3 423276
245 1 0 $a Identifying biomarkers for resistance to novel cisplatin analogues in human breast, lung and prostate cancers.
300 $a 113 p.
500 $a Source: Masters Abstracts International, Volume: 48-02, page: 1046.
500 $a Adviser: Bryan L. Spangelo.
502 $a Thesis (M.S.)--University of Nevada, Las Vegas, 2009.
520 $a Cisplatin is a common therapeutic agent used in cancer treatment. Unfortunately, resistance to cisplatin in addition to severe side effects limits its use in cancer treatment. Two novel cisplatin analogues, 4DB and 4TB were shown to have varying cytotoxicity in lung, breast and prostate cancer cells. The hypothesis for this study states that the differences in 4DB and 4TB cytotoxicity among different tissue types is due to the type and efficiency of DNA repair mechanisms involved in response to these drugs.
520 $a To test the hypothesis, proteins involved in the rate limiting step of nucleotide excision repair (NER) and mismatch repair (MMR) mechanisms were disrupted using stable shRNA transfectants. Survival assays using these cell lines revealed that suppression of MMR enhanced survival in breast and lung cancer cells with respect to cisplatin treatment. Suppression of NER enhanced sensitivity of prostate cancer cells to 4TB.
520 $a Microarray analysis of 4DB treated cells showed repeated over expression of the CHOP gene, indicating DNA damage signalling. Repeated over expression of ZNT1 and MT-1L genes were identified in lung and prostate cells in response to cisplatin and 4TB treatment, indicating their capacity to mitigate drug cytotoxicity in these tissue types.
590 $a School code: 0506.
650 4 $a Biology, Molecular. $3 422925
650 4 $a Chemistry, Biochemistry. $3 422931
650 4 $a Health Sciences, Oncology. $3 422938
690 $a 0307
690 $a 0487
690 $a 0992
710 2 $a University of Nevada, Las Vegas. $3 423277
773 0 $t Masters Abstracts International $g 48-02.
790 1 0 $a Spangelo, Bryan L., $e advisor
790 $a 0506
791 $a M.S.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1472415

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