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Reproducibility in biomedical research[electronic resource] :epistemological and statistical problems /

Record Type:	Electronic resources : Monograph/item
[NT 15000414]:	570.72/4
Title/Author:	Reproducibility in biomedical research : epistemological and statistical problems // Erwin B. Montgomery, Jr.
Author:	Montgomery, Erwin B.,
Published:	London, United Kingdom : : Academic Press, an imprint of Elsevier,, 2019.
Description:	1 online resource
Subject:	Biology - Research.
Subject:	Medicine - Research.
Subject:	Reproducible research.
Subject:	Medicine.
Subject:	Research.
Subject:	NATURE - Reference.
Subject:	SCIENCE - Life Sciences
Subject:	SCIENCE - Life Sciences
ISBN:	9780128176726 (electronic bk.)
ISBN:	0128176725 (electronic bk.)
ISBN:	9780128174432 (print)
ISBN:	0128174439
[NT 15000227]:	Includes bibliographical references and index.
[NT 15000228]:	Front Cover; Reproducibility in Biomedical Research; Copyright Page; Dedication; Quote; Contents; Preface; Prologue; 1 Introduction; Science as Argumentation Within the Experiment and Within the Community; Scientific Argumentation and Logic; The Multifaceted Notion of Irreproducibility; Productive Irreproducibility; Ontology Versus Epistemology; The Use of Logical Formalism; Summary; 2 The Problem of Irreproducibility; Type I and II Errors; Controlling the Inevitability of Irreproducibility Risk; Institutional Responses; Reproducibility and Irreproducibility
Online resource:	https://www.sciencedirect.com/science/book/9780128174432

Reproducibility in biomedical research[electronic resource] :epistemological and statistical problems /
Montgomery, Erwin B.,Jr.,

Reproducibility in biomedical researchepistemological and statistical problems /[electronic resource] :Erwin B. Montgomery, Jr. - London, United Kingdom :Academic Press, an imprint of Elsevier,2019. - 1 online resource

Includes bibliographical references and index.

Front Cover; Reproducibility in Biomedical Research; Copyright Page; Dedication; Quote; Contents; Preface; Prologue; 1 Introduction; Science as Argumentation Within the Experiment and Within the Community; Scientific Argumentation and Logic; The Multifaceted Notion of Irreproducibility; Productive Irreproducibility; Ontology Versus Epistemology; The Use of Logical Formalism; Summary; 2 The Problem of Irreproducibility; Type I and II Errors; Controlling the Inevitability of Irreproducibility Risk; Institutional Responses; Reproducibility and Irreproducibility

ISBN: 9780128176726 (electronic bk.)Subjects--Topical Terms:

342028
Biology
--Research.Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: QH315

Dewey Class. No.: 570.72/4

Reproducibility in biomedical research[electronic resource] :epistemological and statistical problems /
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245 1 0 $a Reproducibility in biomedical research $h [electronic resource] : $b epistemological and statistical problems / $c Erwin B. Montgomery, Jr.
260 $a London, United Kingdom : $b Academic Press, an imprint of Elsevier, $c 2019.
300 $a 1 online resource
504 $a Includes bibliographical references and index.
505 0 $a Front Cover; Reproducibility in Biomedical Research; Copyright Page; Dedication; Quote; Contents; Preface; Prologue; 1 Introduction; Science as Argumentation Within the Experiment and Within the Community; Scientific Argumentation and Logic; The Multifaceted Notion of Irreproducibility; Productive Irreproducibility; Ontology Versus Epistemology; The Use of Logical Formalism; Summary; 2 The Problem of Irreproducibility; Type I and II Errors; Controlling the Inevitability of Irreproducibility Risk; Institutional Responses; Reproducibility and Irreproducibility
505 8 $a Contributions of Logic to Biomedical ResearchReductionism and Conceptual (Broad) Irreproducibility; Variability, Central Tendency, Chaos, and Complexity; Conceptual Reproducibility and the Importance of Hypothesis Generation; Summary; 3 Validity of Biomedical Science, Reproducibility, and Irreproducibility; Science Must Be Doing Something Right and Therein Lies Reproducibility and Productive Irreproducibility; Science Versus Human Knowledge of It; The Necessity of Enabling Assumptions; The Centrality of Reproducibility; The Central Tendency; The Scientific Method; Reductionism; Causality
505 8 $a Special Cases of Irreproducible ReproducibilityScience as Inference to the Best Explanation; Summary; 4 The Logic of Certainty Versus the Logic of Discovery; Certainty, Reproducibility, and Logic; Deductive Logic-Certainty and Limitations; Syllogistic Deduction; Judicious Use of the Fallacy of Four Terms; Partial, Probability, Practical, and Causal Syllogisms; Propositional Logic; Induction; The Duhem-Quine Thesis; Summary; 5 The Logic of Probability and Statistics; The Value of the Logical Perspective in Probability and Statistics
505 8 $a Metaphysics: Ontology Versus Epistemology and Biomedical ReproducibilityIndependence of Probabilities and Regression Toward the Mean; Avoiding the Fallacy of Four Terms; The Conflation of Ontology and Epistemology; Summary; 6 Causation, Process Metaphor, and Reductionism; Practical Syllogism and Beyond; Centrality of Hypothesis to Experimentation and Centrality of Causation to Hypothesis Generation; Reductionism and the Fallacies of Composition and Division; Other Fallacies as Applied to Cause; Discipline in the Principle of Causational and Informational Synonymy; Summary
505 8 $a 7 Case Studies in Clinical Biomedical ResearchForbearance of Repetition; Setting the Stage; Clinical Meaningfulness; Statistics and Internal Validity; Establishing Clinical Meaningfulness; Specific Features to Look for in Case Studies; Case Study-Two Conflicting Studies of Hormone Use in Postmenopausal Women, Which Is Irreproducible?; Summary; 8 Case Studies in Basic Biomedical Research; Forbearance of Repetition; Purpose; Setting the Stage; The Value of a Tool from Its Intended Use; What is Basic Biomedical Research?; Scientific Meaning Versus Statistical Significance
588 0 $a Online resource; title from PDF title page (ScienceDirect, viewed March 19, 2019).
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650 0 $a Medicine $x Research. $3 341824
650 0 $a Reproducible research. $3 753083
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650 1 2 $a Research. $3 378184
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650 7 $a SCIENCE $x Life Sciences $x Biology. $2 bisacsh $3 445379
650 7 $a SCIENCE $x Life Sciences $x General. $2 bisacsh $3 445378
655 0 $a Electronic books. $2 local $3 336502
856 4 0 $u https://www.sciencedirect.com/science/book/9780128174432