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Neuroprotection in Alzheimer's disease[electronic resource] /
紀錄類型:
書目-電子資源 : Monograph/item
杜威分類號:
616.8/311
書名/作者:
Neuroprotection in Alzheimer's disease/ edited by Illana Gozes.
其他作者:
Gozes, Illana,
出版者:
London, United Kingdom : : Academic Press,, 2017.
面頁冊數:
1 online resource
標題:
Alzheimer's disease.
標題:
Alzheimer's disease - Prevention.
標題:
Alzheimer Disease - prevention & control.
標題:
Neuroprotection.
標題:
HEALTH & FITNESS - Diseases
標題:
MEDICAL - Clinical Medicine.
標題:
MEDICAL - Diseases.
標題:
MEDICAL - Evidence-Based Medicine.
標題:
MEDICAL - Internal Medicine.
ISBN:
9780128037126 (electronic bk.)
ISBN:
0128037121 (electronic bk.)
ISBN:
9780128036907
ISBN:
0128036907
內容註:
Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
電子資源:
https://
www.sciencedirect.com/science/book/9780128036907
Neuroprotection in Alzheimer's disease[electronic resource] /
Neuroprotection in Alzheimer's disease
[electronic resource] /edited by Illana Gozes. - London, United Kingdom :Academic Press,2017. - 1 online resource
Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
ISBN: 9780128037126 (electronic bk.)Subjects--Topical Terms:
343910
Alzheimer's disease.
Index Terms--Genre/Form:
753049
Computer network resources.
LC Class. No.: RC523
Dewey Class. No.: 616.8/311
National Library of Medicine Call No.: 2017 D-046
Neuroprotection in Alzheimer's disease[electronic resource] /
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edited by Illana Gozes.
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Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
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Neurotrophic factor small-molecule mimetics for Alzheimer's diseaseEnhancement of neurogenesis and memory by CNTF small-molecule mimetics; CNTF-derived neurogenic/neurotrophic compound, P021, can exert a disease-modifying effect in a transgenic mouse model of AD; Summary and conclusions; References; Chapter 3 -- Animal Models of Alzheimer's Disease; Introduction; The genetics of Alzheimer's disease; Transgenic models of amyloidogenesis; Amyloid precursor protein transgenic mice; PDAPP transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tg2576 transgenic mice; Histopathology.
505
8
$a
BehaviorSynaptic Plasticity; APP23 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; J20 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP knock-in transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP/PS1 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; 5xFAD transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tau transgenic mice; Tau tg mice under tau promoter; Histopathology; Behavior; Synaptic Plasticity; 3xTg transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Animal models for late onset of AD.
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ApoE Transgenic MiceApoE Knock-Out Transgenic Mice; ApoE2/ApoE3/ApoE4 Knock-In Transgenic Mice; GFAP-ApoE4/ApoE Knock-Out Transgenic Mice; ApoE/APP Transgenic Mice; Nonmouse models; Studies in nematodes; Studies in fruit flies; Nontransgenic models for the study of AD; How to choose the right model?; Summary; Acknowledgment; References; Chapter 4 -- Mechanisms of Neuronal Microtubule Loss in Alzheimer's Disease; Introduction; Studies on Alzheimer's brain and animal models; Are microtubules destabilized in the Alzheimer's brain?; Mechanisms of microtubule loss in the Alzheimer's brain.
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Strategies for treatmentAcknowledgments; References; Chapter 5 -- Tau-Centric Therapies for Treating Alzheimer's Disease; Introduction; Six Tau Isoforms-Many Tau Functions; Mechanisms of Tau Toxicity: Phosphorylation, Microtubule Destabilization, and Aggregation; Tau-centric therapeutic strategy 1: targeting tau phosphorylation; Tau Phosphorylation in Physiological and Pathological States; Mechanisms for Stimulating Tau Phosphorylation; Consequences of Phosphorylation; Therapeutic Strategies to Inhibit Tau Phosphorylation; Current State of Affairs.
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https://www.sciencedirect.com/science/book/9780128036907
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