Drug discovery in cancer epigenetics...
Arimondo, Paola,

 

  • Drug discovery in cancer epigenetics[electronic resource] /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    杜威分類號: 616.99/4042
    書名/作者: Drug discovery in cancer epigenetics/ edited by Gerda Egger and Paola Arimondo.
    其他作者: Egger, Gerda,
    出版者: Oxford ; : Academic Press, an imprint of Elsevier,, ©2016.
    面頁冊數: 1 online resource (xxi, 475 p.).
    標題: Cancer - Genetic aspects.
    標題: Epigenetics.
    標題: Antineoplastic agents - Development.
    標題: Cancer - Chemotherapy.
    標題: Drug development.
    標題: Neoplasms - drug therapy.
    標題: Antineoplastic Agents - therapeutic use.
    標題: Neoplasms - genetics.
    標題: Epigenesis, Genetic.
    標題: Drug Discovery.
    ISBN: 9780128024928 (electronic bk.)
    ISBN: 0128024925 (electronic bk.)
    ISBN: 9780128022085
    ISBN: 0128022086
    書目註: Includes bibliographical references and index.
    內容註: Front Cover; Drug Discovery in Cancer Epigenetics; Copyright Page; Contents; List of Contributors; Preface; I. Introduction; 1 Basic Epigenetic Mechanisms and Phenomena; 1.1 Introduction; 1.2 Basic Epigenetic Mechanisms; 1.2.1 DNA Methylation; 1.2.2 DNA Demethylation; 1.2.3 Histone Modifications; 1.2.3.1 Histone Acetylation and Deacetylation; 1.2.3.2 Histone Phosphorylation; 1.2.3.3 Histone Methylation and Demethylation; 1.2.3.4 Chromatin-Remodeling Complexes and Histone Variants; 1.2.4 Noncoding RNAs; 1.3 Epigenetic (Re)Programming; 1.3.1 Epigenetic Asymmetry in the Zygote.
    摘要、提要註: Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic.
    電子資源: https://www.sciencedirect.com/science/book/9780128022085
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