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Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals.

紀錄類型:	書目-電子資源 : Monograph/item
書名/作者:	Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals.
作者:	Kelesidis, Theodoros.
出版者:	Ann Arbor : : ProQuest Dissertations & Theses, , 2016
面頁冊數:	59 p.
附註:	Source: Masters Abstracts International, Volume: 55-04.
Contained By:	Masters Abstracts International55-04(E).
標題:	Medicine.
ISBN:	9781339801605
摘要、提要註:	Objective: HDL function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD) but it is unclear what drives HDL dysfunction in HIV-1 infection. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic HIV-1 infection.

Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals.
Kelesidis, Theodoros.

Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 59 p.

Source: Masters Abstracts International, Volume: 55-04.

Thesis (M.S.)--University of California, Los Angeles, 2016.

Objective: HDL function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD) but it is unclear what drives HDL dysfunction in HIV-1 infection. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic HIV-1 infection.

ISBN: 9781339801605Subjects--Topical Terms:

373206
Medicine.

Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals.
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100 1 $a Kelesidis, Theodoros. $3 686747
245 1 0 $a Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 59 p.
500 $a Source: Masters Abstracts International, Volume: 55-04.
500 $a Adviser: JAMES O. LLOYD-SMITH.
502 $a Thesis (M.S.)--University of California, Los Angeles, 2016.
520 $a Objective: HDL function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD) but it is unclear what drives HDL dysfunction in HIV-1 infection. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic HIV-1 infection.
520 $a Design: Retrospective study of HIV-1 infected males with low overall CVD risk and healthy males with no known CVD risk matched by race to the HIV-1 infected participants.
520 $a Methods: We related parameters previously reported to be associated with HDL function to two different measures of HDL function: reduced antioxidant function (oxidized HDL, HDLox) and HDL-apoA-I exchange (HAE). Multivariable-adjusted linear regression analyses were employed adjusting for false discovery rate (FDR), age, race, body mass index (BMI), CD4 count, viremia, CVD risk, smoking, lipids, apoA-I, albumin.
520 $a Results: In multivariate analysis among HIV-1 infected males (n=166) (median age 45 years, median CD4 T cell count 505 copies/ml, 30.1% were viremic), higher BMI, lower apoA-I and lower albumin were among the most notable correlates of higher HDLox and lower HAE (impaired HDL function)(p<0.05). In HIV-1 uninfected participants lower albumin and higher BMI were associated with lower HAE and higher HDLox, respectively (p≤0.05). HDLox was inversely related to HAE in HIV-1 infected (but not uninfected) individuals (p<0.001).
520 $a Conclusion: Increased HDLox is associated with reduced HDL remodeling in chronic HIV-1 infection. Higher BMI, lower apoA-I and lower albumin were identified as factors associated with abnormal HDL function in chronic HIV-1 infection using two independent methods.
590 $a School code: 0031.
650 4 $a Medicine. $3 373206
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710 2 0 $a University of California, Los Angeles. $b Clinical Research. $3 629872
773 0 $t Masters Abstracts International $g 55-04(E).
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791 $a M.S.
792 $a 2016
793 $a English