Study of the peptide-peptide and pep...
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  • Study of the peptide-peptide and peptide-protein interactions and their applications in cell imaging and nanoparticle surface modification[electronic resource] /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    杜威分類號: 572.65
    書名/作者: Study of the peptide-peptide and peptide-protein interactions and their applications in cell imaging and nanoparticle surface modification/ by Jianpeng Wang.
    作者: Wang, Jianpeng.
    出版者: Berlin, Heidelberg : : Springer Berlin Heidelberg :, 2016.
    面頁冊數: xiii, 96 p. : : ill. (some col.), digital ;; 24 cm.
    Contained By: Springer eBooks
    標題: Peptides.
    標題: Bioconjugates.
    標題: Chemistry.
    標題: Biotechnology.
    標題: Protein Science.
    標題: Nanotechnology.
    標題: Bioorganic Chemistry.
    ISBN: 9783662533994
    ISBN: 9783662533970
    內容註: Introduction -- Biological Active Antifungal Peptides -- Protein Ligands Engineering -- Coiled Coil Binding Induced Covalent Cross-linking -- Cell Surface Receptor Labeling -- Summary and Conclusion.
    摘要、提要註: This thesis focuses on the study of interactions between protein and peptides and their potential applications in cell imaging and nanoparticle surface modification. Drawing inspiration from naturally occurring coiled-coil binding pairs, it proposes a novel covalent peptide tag and probe system, based on the concept of "affinity guided covalent conjugation." This newly established methodology provides complementary resolution to protein labeling, imaging and trafficking. By systematically investigating the coordination interaction between protein and quantum dots using various engineered protein ligands, this thesis proposes a general rule for protein self-assembly on the surface of quantum dots and reports a revolutionized nanobelt protein in accordance with this rule. It is an extraordinary example of interdisciplinary research, providing answers to real-life biological problems from a chemistry perspective.
    電子資源: http://dx.doi.org/10.1007/978-3-662-53399-4
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