大葉大學圖書館 |

Modified nucleic acids in biology and medicine[electronic resource] /

紀錄類型:	書目-電子資源 : Monograph/item
杜威分類號:	572.8
書名/作者:	Modified nucleic acids in biology and medicine/ edited by Stefan Jurga, Volker A. Erdmann, Jan Barciszewski.
其他作者:	Jurga, Stefan.
出版者:	Cham : : Springer International Publishing :, 2016.
面頁冊數:	xiv, 453 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Nucleic acids - Biotechnology.
標題:	Biomedicine.
標題:	Human Genetics.
標題:	Nucleic Acid Chemistry.
標題:	Molecular Medicine.
標題:	Biotechnology.
ISBN:	9783319341750
ISBN:	9783319341736
內容註:	Transfer RNA Modifications: from Biological Functions to Biomedical Applications -- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications -- Sulfur-Modifications in tRNA: Function and Implications for Human Disease -- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium -- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health -- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation -- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification -- Methods for Determination of 2'-O-Me in RNA -- DiadenosineTetraphosphate (Ap4A), in Health and Disease -- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer -- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases -- Effect of Depurination on Cellular and Viral RNA -- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA -- Modifications in Therapeutic Oligonucleotides Improving the Delivery -- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications -- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies -- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy -- Polymerase Reactions that Involve Modified Nucleotides.
摘要、提要註:	This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
電子資源:	http://dx.doi.org/10.1007/978-3-319-34175-0

Modified nucleic acids in biology and medicine[electronic resource] /
Modified nucleic acids in biology and medicine[electronic resource] /edited by Stefan Jurga, Volker A. Erdmann, Jan Barciszewski. - Cham :Springer International Publishing :2016. - xiv, 453 p. :ill., digital ;24 cm. - RNA technologies,2197-9731. - RNA technologies..

Transfer RNA Modifications: from Biological Functions to Biomedical Applications -- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications -- Sulfur-Modifications in tRNA: Function and Implications for Human Disease -- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium -- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health -- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation -- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification -- Methods for Determination of 2'-O-Me in RNA -- DiadenosineTetraphosphate (Ap4A), in Health and Disease -- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer -- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases -- Effect of Depurination on Cellular and Viral RNA -- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA -- Modifications in Therapeutic Oligonucleotides Improving the Delivery -- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications -- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies -- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy -- Polymerase Reactions that Involve Modified Nucleotides.

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

ISBN: 9783319341750

Standard No.: 10.1007/978-3-319-34175-0doiSubjects--Topical Terms:

466898
Nucleic acids
--Biotechnology.

LC Class. No.: QP620

Dewey Class. No.: 572.8

Modified nucleic acids in biology and medicine[electronic resource] /
LDR:04002nmm a2200325 a 4500 001 461936
003 DE-He213
005 20161212165125.0
006 m d
007 cr nn 008maaau
008 170223s2016 gw s 0 eng d
020 $a 9783319341750 $q (electronic bk.)
020 $a 9783319341736 $q (paper)
024 7 $a 10.1007/978-3-319-34175-0 $2 doi
035 $a 978-3-319-34175-0
040 $a GP $c GP
041 0 $a eng
050 4 $a QP620
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
082 0 4 $a 572.8 $2 23
090 $a QP620 $b .M692 2016
245 0 0 $a Modified nucleic acids in biology and medicine $h [electronic resource] / $c edited by Stefan Jurga, Volker A. Erdmann, Jan Barciszewski.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a xiv, 453 p. : $b ill., digital ; $c 24 cm.
490 1 $a RNA technologies, $x 2197-9731
505 0 $a Transfer RNA Modifications: from Biological Functions to Biomedical Applications -- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications -- Sulfur-Modifications in tRNA: Function and Implications for Human Disease -- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium -- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health -- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation -- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification -- Methods for Determination of 2'-O-Me in RNA -- DiadenosineTetraphosphate (Ap4A), in Health and Disease -- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer -- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases -- Effect of Depurination on Cellular and Viral RNA -- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA -- Modifications in Therapeutic Oligonucleotides Improving the Delivery -- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications -- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies -- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy -- Polymerase Reactions that Involve Modified Nucleotides.
520 $a This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
650 0 $a Nucleic acids $x Biotechnology. $3 466898
650 1 4 $a Biomedicine. $3 463454
650 2 4 $a Human Genetics. $3 464334
650 2 4 $a Nucleic Acid Chemistry. $3 466899
650 2 4 $a Molecular Medicine. $3 463625
650 2 4 $a Biotechnology. $3 340178
700 1 $a Jurga, Stefan. $3 626797
700 1 $a Erdmann, Volker A. $3 626796
700 1 $a Barciszewski, Jan. $3 626798
710 2 $a SpringerLink (Online service) $3 463450
773 0 $t Springer eBooks
830 0 $a RNA technologies. $3 626799
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-34175-0
950 $a Biomedical and Life Sciences (Springer-11642)