大葉大學圖書館 |

Towards a new neuromorphology[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	612.8
書名/作者:	Towards a new neuromorphology/ by Rudolf Nieuwenhuys, Luis Puelles.
作者:	Nieuwenhuys, Rudolf.
其他作者:	Puelles, Luis.
出版者:	Cham : : Springer International Publishing :, 2016.
面頁冊數:	xv, 344 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Neurosciences.
標題:	Brain - Development.
標題:	Biomedicine.
標題:	Neurobiology.
標題:	Neurology.
ISBN:	9783319256931
ISBN:	9783319256924
內容註:	1. From classic to modern neuromorphology, an introductory overview -- 2. The neural plate -- 3. From neural plate to neural tube -- 4. The neural tube -- 5. The axis of the brain, its flexures and correlates -- 6. The (complex) rostral part of the brain -- Summary -- 7. The natural coordinate system of the CNS -- 8. The fundamental morphological units (FMUs) of the CNS -- 9. The structural pattern, 'Bauplan' or 'blueprint' of the CNS -- 10. The development of grisea -- 11. The 'wiring' of the brain -- 12. General summary, conclusions and perspective -- References -- Index.
摘要、提要註:	This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essentially organized into transverse neural segments or neuromeres and longitudinal zones which follow the curved axis of the brain. (2) The FMUs initially represent thin neuroepithelial fields; in the course of further development they are transformed into three-dimensional radial units, extending from the ventricular surface to the meningeal surface of the brain. (3) The principal histogenetic processes, including cellular proliferation, cell migration and differentiation, essentially take place within the confines of these radial units, controlled by characteristic sets of developmental regulatory genes. (4) Although most developing neurons migrate radially and settle within their own FMU, at many locations neuroblasts leave the FMU where they were produced and migrate tangentially to other nearby or remote territories, colonizing parts of foreign FMUs. (5) Many structural complexes in the adult brain, including the cerebral and cerebellar cortices, are the products of radial and tangential intermingling of migrated cell contingents. (6) By using appropriate molecular markers, all neuron types in the adult CNS can be traced back to a specific progenitor zone within a specific FMU, and the progeny of any FMU can be traced to their final positions with the help of selective labeling approaches. (7) Early outgrowing axons form bundles, which tend to pass close to the border zones of the radial units. By means of their molecularly diversely tuned growth cones, these extending axons decide how to behave at each boundary they encounter, sometimes even reorienting at right angles. Collectively these early axonal bundles form a checkerboard-like scaffold, which accentuates the molecular regionalization of the CNS and leads to the formation of topographically ordered synaptic fields. The book covers all of these aspects in detail, providing a morphologic model (blueprint) that highlights the natural coordinates of CNS structure resulting from the conserved molecularly controlled shaping phenomena within morphogenetic fields.
電子資源:	http://dx.doi.org/10.1007/978-3-319-25693-1

Towards a new neuromorphology[electronic resource] /
Nieuwenhuys, Rudolf.

Towards a new neuromorphology[electronic resource] /by Rudolf Nieuwenhuys, Luis Puelles. - Cham :Springer International Publishing :2016. - xv, 344 p. :ill., digital ;24 cm.

1. From classic to modern neuromorphology, an introductory overview -- 2. The neural plate -- 3. From neural plate to neural tube -- 4. The neural tube -- 5. The axis of the brain, its flexures and correlates -- 6. The (complex) rostral part of the brain -- Summary -- 7. The natural coordinate system of the CNS -- 8. The fundamental morphological units (FMUs) of the CNS -- 9. The structural pattern, 'Bauplan' or 'blueprint' of the CNS -- 10. The development of grisea -- 11. The 'wiring' of the brain -- 12. General summary, conclusions and perspective -- References -- Index.

This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essentially organized into transverse neural segments or neuromeres and longitudinal zones which follow the curved axis of the brain. (2) The FMUs initially represent thin neuroepithelial fields; in the course of further development they are transformed into three-dimensional radial units, extending from the ventricular surface to the meningeal surface of the brain. (3) The principal histogenetic processes, including cellular proliferation, cell migration and differentiation, essentially take place within the confines of these radial units, controlled by characteristic sets of developmental regulatory genes. (4) Although most developing neurons migrate radially and settle within their own FMU, at many locations neuroblasts leave the FMU where they were produced and migrate tangentially to other nearby or remote territories, colonizing parts of foreign FMUs. (5) Many structural complexes in the adult brain, including the cerebral and cerebellar cortices, are the products of radial and tangential intermingling of migrated cell contingents. (6) By using appropriate molecular markers, all neuron types in the adult CNS can be traced back to a specific progenitor zone within a specific FMU, and the progeny of any FMU can be traced to their final positions with the help of selective labeling approaches. (7) Early outgrowing axons form bundles, which tend to pass close to the border zones of the radial units. By means of their molecularly diversely tuned growth cones, these extending axons decide how to behave at each boundary they encounter, sometimes even reorienting at right angles. Collectively these early axonal bundles form a checkerboard-like scaffold, which accentuates the molecular regionalization of the CNS and leads to the formation of topographically ordered synaptic fields. The book covers all of these aspects in detail, providing a morphologic model (blueprint) that highlights the natural coordinates of CNS structure resulting from the conserved molecularly controlled shaping phenomena within morphogenetic fields.

ISBN: 9783319256931

Standard No.: 10.1007/978-3-319-25693-1doiSubjects--Topical Terms:

372208
Neurosciences.

LC Class. No.: RC343.3

Dewey Class. No.: 612.8

Towards a new neuromorphology[electronic resource] /
LDR:03955nam a2200313 a 4500 001 455487
003 DE-He213
005 20160803145114.0
006 m d
007 cr nn 008maaau
008 161227s2016 gw s 0 eng d
020 $a 9783319256931 $q (electronic bk.)
020 $a 9783319256924 $q (paper)
024 7 $a 10.1007/978-3-319-25693-1 $2 doi
035 $a 978-3-319-25693-1
040 $a GP $c GP
041 0 $a eng
050 4 $a RC343.3
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
082 0 4 $a 612.8 $2 23
090 $a RC343.3 $b .N682 2016
100 1 $a Nieuwenhuys, Rudolf. $3 653913
245 1 0 $a Towards a new neuromorphology $h [electronic resource] / $c by Rudolf Nieuwenhuys, Luis Puelles.
260 $a Cham : $c 2016. $b Springer International Publishing : $b Imprint: Springer,
300 $a xv, 344 p. : $b ill., digital ; $c 24 cm.
505 0 $a 1. From classic to modern neuromorphology, an introductory overview -- 2. The neural plate -- 3. From neural plate to neural tube -- 4. The neural tube -- 5. The axis of the brain, its flexures and correlates -- 6. The (complex) rostral part of the brain -- Summary -- 7. The natural coordinate system of the CNS -- 8. The fundamental morphological units (FMUs) of the CNS -- 9. The structural pattern, 'Bauplan' or 'blueprint' of the CNS -- 10. The development of grisea -- 11. The 'wiring' of the brain -- 12. General summary, conclusions and perspective -- References -- Index.
520 $a This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essentially organized into transverse neural segments or neuromeres and longitudinal zones which follow the curved axis of the brain. (2) The FMUs initially represent thin neuroepithelial fields; in the course of further development they are transformed into three-dimensional radial units, extending from the ventricular surface to the meningeal surface of the brain. (3) The principal histogenetic processes, including cellular proliferation, cell migration and differentiation, essentially take place within the confines of these radial units, controlled by characteristic sets of developmental regulatory genes. (4) Although most developing neurons migrate radially and settle within their own FMU, at many locations neuroblasts leave the FMU where they were produced and migrate tangentially to other nearby or remote territories, colonizing parts of foreign FMUs. (5) Many structural complexes in the adult brain, including the cerebral and cerebellar cortices, are the products of radial and tangential intermingling of migrated cell contingents. (6) By using appropriate molecular markers, all neuron types in the adult CNS can be traced back to a specific progenitor zone within a specific FMU, and the progeny of any FMU can be traced to their final positions with the help of selective labeling approaches. (7) Early outgrowing axons form bundles, which tend to pass close to the border zones of the radial units. By means of their molecularly diversely tuned growth cones, these extending axons decide how to behave at each boundary they encounter, sometimes even reorienting at right angles. Collectively these early axonal bundles form a checkerboard-like scaffold, which accentuates the molecular regionalization of the CNS and leads to the formation of topographically ordered synaptic fields. The book covers all of these aspects in detail, providing a morphologic model (blueprint) that highlights the natural coordinates of CNS structure resulting from the conserved molecularly controlled shaping phenomena within morphogenetic fields.
650 0 $a Neurosciences. $3 372208
650 0 $a Brain $x Development. $3 653915
650 1 4 $a Biomedicine. $3 463454
650 2 4 $a Neurobiology. $3 385450
650 2 4 $a Neurology. $3 402687
700 1 $a Puelles, Luis. $3 653914
710 2 $a SpringerLink (Online service) $3 463450
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-25693-1
950 $a Biomedical and Life Sciences (Springer-11642)