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Interleukin-27[electronic resource] :biological properties and clinical application /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	571.96
書名/作者:	Interleukin-27 : biological properties and clinical application // by Marek Jankowski, Tomasz Wandtke.
作者:	Jankowski, Marek.
其他作者:	Wandtke, Tomasz.
出版者:	Cham : : Springer International Publishing :, 2016.
面頁冊數:	vi, 86 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Interleukins.
標題:	Biomedicine.
標題:	Immunology.
標題:	Cytokines and Growth Factors.
ISBN:	9783319396644
ISBN:	9783319396620
內容註:	IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.
摘要、提要註:	This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
電子資源:	http://dx.doi.org/10.1007/978-3-319-39664-4

Interleukin-27[electronic resource] :biological properties and clinical application /
Jankowski, Marek.

Interleukin-27biological properties and clinical application /[electronic resource] :by Marek Jankowski, Tomasz Wandtke. - Cham :Springer International Publishing :2016. - vi, 86 p. :ill., digital ;24 cm. - SpringerBriefs in immunology,2194-2773. - SpringerBriefs in immunology..

IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

ISBN: 9783319396644

Standard No.: 10.1007/978-3-319-39664-4doiSubjects--Topical Terms:

646411
Interleukins.

LC Class. No.: QR185.8.I56

Dewey Class. No.: 571.96

Interleukin-27[electronic resource] :biological properties and clinical application /
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