大葉大學圖書館 |

The smoothened receptor in cancer and regenerative medicine[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	615.1
書名/作者:	The smoothened receptor in cancer and regenerative medicine/ edited by Martial Ruat.
其他作者:	Ruat, Martial.
出版者:	Cham : : Springer International Publishing :, 2015.
面頁冊數:	vii, 210 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Regenerative medicine - Methods.
標題:	Regenerative medicine - Cancer.
標題:	Chemistry.
標題:	Medicinal Chemistry.
標題:	Receptors.
標題:	Cancer Research.
ISBN:	9783319197555 (electronic bk.)
ISBN:	9783319197548 (paper)
內容註:	Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.
摘要、提要註:	Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series topics in medicinal chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
電子資源:	http://dx.doi.org/10.1007/978-3-319-19755-5

The smoothened receptor in cancer and regenerative medicine[electronic resource] /
The smoothened receptor in cancer and regenerative medicine[electronic resource] /edited by Martial Ruat. - Cham :Springer International Publishing :2015. - vii, 210 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,161862-2461 ;. - Topics in medicinal chemistry ;13..

Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series topics in medicinal chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

ISBN: 9783319197555 (electronic bk.)

Standard No.: 10.1007/978-3-319-19755-5doiSubjects--Topical Terms:

626967
Regenerative medicine
--Methods.

LC Class. No.: RM300

Dewey Class. No.: 615.1

The smoothened receptor in cancer and regenerative medicine[electronic resource] /
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