大葉大學圖書館 |

Medicinal chemistry of anticancer drugs[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.994061
書名/作者:	Medicinal chemistry of anticancer drugs/ Carmen Avenda�no and J. Carlos Men�endez.
作者:	Avenda�no, Carmen.
其他作者:	Men�endez, J. Carlos
出版者:	Amsterdam ; : Elsevier,, 2008.
面頁冊數:	xv, 442 p. : : ill. ;; 25 cm.
標題:	Cancer - Chemotherapy.
標題:	Drugs - Design.
標題:	Pharmaceutical chemistry.
ISBN:	9780444528247
ISBN:	0444528245
書目註:	Includes bibliographical references and index.
內容註:	1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10.Other approaches to targeted therapy -- 11.Drug targeting in anticancer chemotherapy -- 12.Resistance to antitumour agents and drugs that modulate it -- 13.Cancer chemoprevention.
摘要、提要註:	Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.
電子資源:	An electronic book accessible through the World Wide Web; click for information

Medicinal chemistry of anticancer drugs[electronic resource] /
Avenda�no, Carmen.

Medicinal chemistry of anticancer drugs[electronic resource] /Carmen Avenda�no and J. Carlos Men�endez. - 1st ed. - Amsterdam ;Elsevier,2008. - xv, 442 p. :ill. ;25 cm.

Includes bibliographical references and index.

1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10.Other approaches to targeted therapy -- 11.Drug targeting in anticancer chemotherapy -- 12.Resistance to antitumour agents and drugs that modulate it -- 13.Cancer chemoprevention.

Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780444528247

Source: 114030:114121Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

382675
Cancer
--Chemotherapy.Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: RC271.C5 / A94 2008eb

Dewey Class. No.: 616.994061

Medicinal chemistry of anticancer drugs[electronic resource] /
LDR:04112cam 2200349Ia 4500 001 347603
003 OCoLC
005 20110615082933.0
006 m d
007 cr cn|||||||||
008 111130s2008 ne a ob 001 0 eng d
020 $a 9780444528247
020 $a 0444528245
029 1 $a NZ1 $b 13068740
035 $a (OCoLC)272382250
035 $a ocn272382250
037 $a 114030:114121 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $b eng $c OPELS $d OPELS
049 $a TEFA
050 1 4 $a RC271.C5 $b A94 2008eb
082 0 4 $a 616.994061 $2 22
100 1 $a Avenda�no, Carmen. $3 431504
245 1 0 $a Medicinal chemistry of anticancer drugs $h [electronic resource] / $c Carmen Avenda�no and J. Carlos Men�endez.
250 $a 1st ed.
260 $a Amsterdam ; $a Boston : $b Elsevier, $c 2008.
300 $a xv, 442 p. : $b ill. ; $c 25 cm.
504 $a Includes bibliographical references and index.
505 0 $a 1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10.Other approaches to targeted therapy -- 11.Drug targeting in anticancer chemotherapy -- 12.Resistance to antitumour agents and drugs that modulate it -- 13.Cancer chemoprevention.
505 0 $a Introduction -- Antimetabolites -- Anticancer drugs that inhibit hormone action -- Anticancer drugs acting via radical species, photosensitizers and photodynamic therapy of cancer -- DNA alkylating agents -- Alkylating and non-alkylating compounds interacting with the DNA minor groove -- DNA intercalators and topoisomerase inhibitors -- Anticancer drugs targeting tubulin and microtubules -- Drugs that inhibit signalling pathways for tumor cell growth and proliferation -- Other approaches to targeted therapy -- Drug targeting in anticancer chemotherapy -- Drugs that modulate resistance to antitumor agents -- Cancer chemoprevention.
520 $a Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2008. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Nov. 14, 2008). $n Access may be restricted to users at subscribing institutions.
650 0 $a Cancer $x Chemotherapy. $3 382675
650 0 $a Drugs $x Design. $3 424032
650 0 $a Pharmaceutical chemistry. $3 223006
655 7 $a Electronic books. $2 local $3 336502
700 1 $a Men�endez, J. Carlos $q (Jos�e Carlos) $3 431505
710 2 $a ScienceDirect (Online service) $3 365609
776 1 $c Original $z 9780444528247 $z 0444528245 $w (OCoLC)227271605
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780444528247 $z An electronic book accessible through the World Wide Web; click for information
994 $a C0 $b TEF