Osteoporosis[electronic resource] /
Marcus, Robert, (1940-)

 

  • Osteoporosis[electronic resource] /
  • 紀錄類型: 書目-語言資料,印刷品 : Monograph/item
    杜威分類號: 616.716
    書名/作者: Osteoporosis/ edited by Robert Marcus ... [et al.].
    其他作者: Marcus, Robert,
    出版者: Amsterdam ; : Elsevier Academic Press,, c2008.
    面頁冊數: 2 v. (xxv, 1941 p., [16] p. of plates) : : ill. ;; 29 cm.
    標題: Osteoporosis - pathology.
    標題: Fractures, Bone - pathology.
    標題: Osteoporosis - therapy.
    標題: Osteoporosis.
    ISBN: 9780123705440
    ISBN: 0123705444
    書目註: Includes bibliographical references and index.
    內容註: Introduction -- The Bone Organ System: Form and Function -- The Nature of Osteoporosis -- The Economics of Osteoporosis -- Reflections on Osteoporosis -- Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the -- Understanding of Osteoporosis -- Basic Science/Bone Biology -- Osteoblast Biology -- Osteoclast Biology -- Osteocytes -- The Regulatory Role of Matrix Proteins in Mineralization of Bone -- Development of the Skeleton -- Mouse Genetics as a Tool to Study Bone Development and Physiology -- Parathyroid Hormone and Parathyroid Hormone-Related Protein -- Vitamin D: Biology, Action, and Clinical Implications -- Regulation of Bone Cell Function by Estrogens -- Androgens and Skeletal Biology: Basic Mechanisms -- Phosphatonins -- Wnt Signaling in Bone -- Cytokines and Bone Remodeling -- Skeletal Growth Factors -- Intercellular Communication During Bone Remodeling -- Structural and Biomechanics -- Skeletal Development: Mechanical Consequences of Growth, Aging and Disease -- Inhibition of Osteoporosis by Biophysical Intervention -- Biomechanics of Age-Related Fractures -- Bone Quality -- Epidemiology & Risk Factors -- Epidemiologic Methods in Studies of Osteoporosis -- Race, Ethnicity and Osteoporosis -- The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions -- Bone Mineral Acquisition in Utero and During Infancy and Childhood -- Bone Acquisition in Adolescence -- Genetic Determinants of Osteoporosis -- Nutrition and Risk for Osteoporosis -- Physical Activity in Prevention of Osteoporosis and Associated Fractures -- Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis -- Non-Skeletal Risk Factors for Osteoporosis and Fractures -- Falls as Risk Factors for Fracture -- Assessment of Fracture Risk -- Outcomes of Osteoporotic Fractures -- Pathophysiology -- Local and Systemic Factors in the Pathogenesis of Osteoporosis -- Animal Models for Osteoporosis -- Estrogen, Bone Homeostasis and Osteoporosis -- Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss -- Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization -- Osteoporosis in Childhood and Adolescence -- Glucocorticoid-Induced Osteoporosis -- Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach -- Mechanisms of Immobilization-induced Bone Loss -- Leptin-Dependent Regulation of Bone Mass -- Thyroid Hormone and the Skeleton -- Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease -- The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis -- Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis -- Osteoporosis Associated with Illnesses and Medications -- Transplantation Osteoporosis -- Osteoporosis Associated with Cancer Therapy -- Osteoporosis Associated with Pregnancy -- Osteoporosis Associated with Rheumatologic Disease -- Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks -- Localized Osteoporosis -- Evaluation and Management -- Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis -- Who Should be Screened: Who Should be Treated? -- Radiology of Osteoporosis -- Clinical Use of Bone Densitometry -- Biochemical Markers of Bone Turnover in Osteoporosis -- The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis -- An Orthopedic Perspective of Osteoporosis -- Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs -- Pharmacology and Therapeutics -- Design Considerations for Clinical Investigations of Osteoporosis -- Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials -- Evidence-Based Osteoporosis Care -- The Role of Calcium in the Treatment of Osteoporosis -- Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis -- Estrogen Therapy: Prevention and Treatment of Osteoporosis -- Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens -- Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis -- Calcitonin in Osteoporosis -- Strontium Therapy for Osteoporosis -- Androgens -- Treatment with PTH Peptides -- Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis -- New approaches to Osteoporosis Therapeutics.
    摘要、提要註: Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere.
    電子資源: An electronic book accessible through the World Wide Web; click for information
評論
Export
取書館別
 
 
變更密碼
登入