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The functional nucleus[electronic re...

Bazett-Jones, David P.

The functional nucleus[electronic resource] /

紀錄類型:	書目-電子資源 : Monograph/item
杜威分類號:	571.66
書名/作者:	The functional nucleus/ edited by David P. Bazett-Jones, Graham Dellaire.
其他作者:	Dellaire, Graham.
出版者:	Cham : : Springer International Publishing :, 2016.
面頁冊數:	vi, 513 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Cell nuclei.
標題:	Life Sciences.
標題:	Nucleic Acid Chemistry.
標題:	Cell Biology.
標題:	Cytogenetics.
ISBN:	9783319388823
ISBN:	9783319388809
摘要、提要註:	This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
電子資源:	http://dx.doi.org/10.1007/978-3-319-38882-3

The functional nucleus[electronic resource] /
The functional nucleus[electronic resource] /edited by David P. Bazett-Jones, Graham Dellaire. - Cham :Springer International Publishing :2016. - vi, 513 p. :ill., digital ;24 cm.

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

ISBN: 9783319388823

Standard No.: 10.1007/978-3-319-38882-3doiSubjects--Topical Terms:

184640
Cell nuclei.

LC Class. No.: QH595

Dewey Class. No.: 571.66

The functional nucleus[electronic resource] /
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245 0 4 $a The functional nucleus $h [electronic resource] / $c edited by David P. Bazett-Jones, Graham Dellaire.
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520 $a This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
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650 1 4 $a Life Sciences. $3 463509
650 2 4 $a Nucleic Acid Chemistry. $3 466899
650 2 4 $a Cell Biology. $3 463594
650 2 4 $a Cytogenetics. $3 197797
700 1 $a Dellaire, Graham. $3 672531
700 1 $a Bazett-Jones, David P. $3 672530
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