Translational neuropsychopharmacolog...
Robbins, Trevor W.

 

  • Translational neuropsychopharmacology[electronic resource] /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    杜威分類號: 615.78
    書名/作者: Translational neuropsychopharmacology/ edited by Trevor W. Robbins, Barbara J. Sahakian.
    其他作者: Robbins, Trevor W.
    出版者: Cham : : Springer International Publishing :, 2016.
    面頁冊數: xii, 498 p. : : ill., digital ;; 24 cm.
    Contained By: Springer eBooks
    標題: Neuropsychopharmacology.
    標題: Biomedicine.
    標題: Neurosciences.
    標題: Psychopharmacology.
    標題: Pharmacology/Toxicology.
    ISBN: 9783319339139
    ISBN: 9783319339115
    內容註: Translational mouse models of autism; Advancing towards pharmacological therapeutics -- Translatable and back-translatable measurement of impulsivity and compulsivity; convergent and divergent processes -- Translational models of gambling-related decision-making -- Translational research on nicotine dependence -- The need for treatment-responsive translatable biomarkers in alcoholism research -- On the road to translation for PTSD treatment: theoretical and practical considerations of the use of human models of conditioned fear for drug development -- Translational approaches targeting reconsolidation -- Translational assessment of reward and motivational deficits in psychiatric disorders -- Affective biases in humans and animals. Robinson -- Locomotor profiling from the rodents to the clinic and back again -- Animal models of sensori-motor gating in schizophrenia: Are they still relevant? -- Attention and the cholinergic system: relevance to schizophrenia -- Attentional-set-shifting across species -- Relating Translational Neuroimaging and Amperometric Endpoints: Utility for Neuropsychiatric Drug Discovery -- Cognitive translation using the rodent touchscreen test approach -- The Paired Associates Learning (PAL) Test: 30 years of CANTAB Translational Neuroscience From Laboratory to Bedside in Dementia Research -- Translational approaches to experimental medicine.
    摘要、提要註: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
    電子資源: http://dx.doi.org/10.1007/978-3-319-33913-9
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