大葉大學圖書館 |

Fundamentals of neurodegeneration and protein misfolding disorders[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.3995
書名/作者:	Fundamentals of neurodegeneration and protein misfolding disorders/ by Martin Beckerman.
作者:	Beckerman, Martin.
出版者:	Cham : : Springer International Publishing :, 2015.
面頁冊數:	xxii, 378 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Proteins - Metabolism
標題:	Protein folding.
標題:	Nervous system - Degeneration.
標題:	Biomedicine.
標題:	Neurosciences.
標題:	Biophysics and Biological Physics.
標題:	Protein Science.
標題:	Biomedical Engineering.
標題:	Neurology.
標題:	Medicinal Chemistry.
ISBN:	9783319221175
ISBN:	9783319221168
內容註:	Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer's Disease -- Parkinson's Disease -- Huntington's Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.
摘要、提要註:	This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
電子資源:	http://dx.doi.org/10.1007/978-3-319-22117-5

Fundamentals of neurodegeneration and protein misfolding disorders[electronic resource] /
Beckerman, Martin.

Fundamentals of neurodegeneration and protein misfolding disorders[electronic resource] /by Martin Beckerman. - Cham :Springer International Publishing :2015. - xxii, 378 p. :ill., digital ;24 cm. - Biological and medical physics, biomedical engineering,1618-7210. - Biological and medical physics, biomedical engineering..

Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer's Disease -- Parkinson's Disease -- Huntington's Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

ISBN: 9783319221175

Standard No.: 10.1007/978-3-319-22117-5doiSubjects--Topical Terms:

488280
Proteins
--Metabolism

LC Class. No.: RC632.P7

Dewey Class. No.: 616.3995

Fundamentals of neurodegeneration and protein misfolding disorders[electronic resource] /
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