大葉大學圖書館 |

Neuronal tissue-nonspecific alkaline phosphatase (TNAP)[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	572.7553
書名/作者:	Neuronal tissue-nonspecific alkaline phosphatase (TNAP)/ edited by Caroline Fonta, Laszlo Negyessy.
其他作者:	Fonta, Caroline.
出版者:	Dordrecht : : Springer Netherlands :, 2015.
面頁冊數:	xxii, 395 p. : : ill., digital ;; 24 cm.
Contained By:	Springer eBooks
標題:	Alkaline phosphatase.
標題:	Biomedicine.
標題:	Human Physiology.
標題:	Animal Physiology.
標題:	Developmental Biology.
標題:	Neurosciences.
ISBN:	9789401771979 (electronic bk.)
ISBN:	9789401771962 (paper)
內容註:	1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer's disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index.
摘要、提要註:	Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.
電子資源:	http://dx.doi.org/10.1007/978-94-017-7197-9

Neuronal tissue-nonspecific alkaline phosphatase (TNAP)[electronic resource] /
Neuronal tissue-nonspecific alkaline phosphatase (TNAP)[electronic resource] /edited by Caroline Fonta, Laszlo Negyessy. - Dordrecht :Springer Netherlands :2015. - xxii, 395 p. :ill., digital ;24 cm. - Subcellular biochemistry,v.760306-0225 ;. - Subcellular biochemistry ;v.56..

1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer's disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index.

Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.

ISBN: 9789401771979 (electronic bk.)

Standard No.: 10.1007/978-94-017-7197-9doiSubjects--Topical Terms:

633095
Alkaline phosphatase.

LC Class. No.: QP609.A4

Dewey Class. No.: 572.7553

Neuronal tissue-nonspecific alkaline phosphatase (TNAP)[electronic resource] /
LDR:03335nam a2200325 a 4500 001 442880
003 DE-He213
005 20160219105059.0
006 m d
007 cr nn 008maaau
008 160715s2015 ne s 0 eng d
020 $a 9789401771979 (electronic bk.)
020 $a 9789401771962 (paper)
024 7 $a 10.1007/978-94-017-7197-9 $2 doi
035 $a 978-94-017-7197-9
040 $a GP $c GP
041 0 $a eng
050 4 $a QP609.A4
072 7 $a MFG $2 bicssc
072 7 $a MED075000 $2 bisacsh
082 0 4 $a 572.7553 $2 23
090 $a QP609.A4 $b N494 2015
245 0 0 $a Neuronal tissue-nonspecific alkaline phosphatase (TNAP) $h [electronic resource] / $c edited by Caroline Fonta, Laszlo Negyessy.
260 $a Dordrecht : $b Springer Netherlands : $b Imprint: Springer, $c 2015.
300 $a xxii, 395 p. : $b ill., digital ; $c 24 cm.
490 1 $a Subcellular biochemistry, $x 0306-0225 ; $v v.76
505 0 $a 1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer's disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index.
520 $a Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.
650 0 $a Alkaline phosphatase. $3 633095
650 1 4 $a Biomedicine. $3 463454
650 2 4 $a Human Physiology. $3 463624
650 2 4 $a Animal Physiology. $3 466575
650 2 4 $a Developmental Biology. $3 428069
650 2 4 $a Neurosciences. $3 372208
700 1 $a Fonta, Caroline. $3 633093
700 1 $a Negyessy, Laszlo. $3 633094
710 2 $a SpringerLink (Online service) $3 463450
773 0 $t Springer eBooks
830 0 $a Subcellular biochemistry ; $v v.56. $3 465213
856 4 0 $u http://dx.doi.org/10.1007/978-94-017-7197-9
950 $a Biomedical and Life Sciences (Springer-11642)