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Microbial treatment strategies: An i...

Brantner, Justin S.

Microbial treatment strategies: An integrative approach.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Microbial treatment strategies: An integrative approach.
Author:	Brantner, Justin S.
Description:	205 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-03(E), Section: B.
Contained By:	Dissertation Abstracts International77-03B(E).
Subject:	Microbiology.
Subject:	Biochemistry.
Subject:	Biology.
ISBN:	9781339161723
[NT 15000229]:	Understanding microbial treatment strategies represents a unique challenge for integrative biologists. From one viewpoint, the metabolic diversity of naturally occurring bacteria could be utilized to develop passive treatment strategies that target specific systems impacted by environmental contamination. On the other hand, from a medical perspective many bacteria are capable of establishing residence within host environments often resulting in difficult to treat infections. The purpose of this research was to explore two specific scenarios, acid mine drainage (AMD) and cystic fibrosis (CF), as a means to further develop potentially useful microbial treatment strategies.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3730050

Microbial treatment strategies: An integrative approach.
Brantner, Justin S.

Microbial treatment strategies: An integrative approach. - 205 p.

Source: Dissertation Abstracts International, Volume: 77-03(E), Section: B.

Thesis (Ph.D.)--The University of Akron, 2015.

Understanding microbial treatment strategies represents a unique challenge for integrative biologists. From one viewpoint, the metabolic diversity of naturally occurring bacteria could be utilized to develop passive treatment strategies that target specific systems impacted by environmental contamination. On the other hand, from a medical perspective many bacteria are capable of establishing residence within host environments often resulting in difficult to treat infections. The purpose of this research was to explore two specific scenarios, acid mine drainage (AMD) and cystic fibrosis (CF), as a means to further develop potentially useful microbial treatment strategies.

ISBN: 9781339161723Subjects--Topical Terms:

182563
Microbiology.

Microbial treatment strategies: An integrative approach.
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100 1 $a Brantner, Justin S. $3 630089
245 1 0 $a Microbial treatment strategies: An integrative approach.
300 $a 205 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-03(E), Section: B.
500 $a Adviser: John M. Senko.
502 $a Thesis (Ph.D.)--The University of Akron, 2015.
520 $a Understanding microbial treatment strategies represents a unique challenge for integrative biologists. From one viewpoint, the metabolic diversity of naturally occurring bacteria could be utilized to develop passive treatment strategies that target specific systems impacted by environmental contamination. On the other hand, from a medical perspective many bacteria are capable of establishing residence within host environments often resulting in difficult to treat infections. The purpose of this research was to explore two specific scenarios, acid mine drainage (AMD) and cystic fibrosis (CF), as a means to further develop potentially useful microbial treatment strategies.
520 $a In order to develop effective passive treatment options for water pollution caused by AMD, it becomes necessary to first evaluate how natural soil bacteria respond to sustained AMD intrusion. Data presented shows how the population of soil microorganisms from an AMD site exhibiting "sheet flow" characteristics shifts from a highly diverse community towards a less metabolically robust community composed of higher relative percentages of organisms capable of metabolic iron(II) oxidation. Data is also shown for depth dependent organization of microbial communities through a "mature" iron mound that has formed as a result of continuous iron(II) oxidation and subsequent precipitation of various iron(III)-(hydr)oxides.
520 $a From a medical perspective, more clinically relevant microbial treatment methodologies are necessary to combat infections such as those commonly caused by Pseudomonas aeruginosa in the lungs of CF patients. Utilizing conditions that better approximate the chemical composition and bacterial population of the CF lung environment, various antimicrobial compounds (including two novel silver carbene complexes) were examined for efficacy against planktonic and biofilm phenotypes of multiple strains of P. aeruginosa. Data shows that mucin (a key component of the CF lung environment) concentration greatly impacts the efficacy of multiple classes of antimicrobial compounds. Further, it was found that silver carbene complexes were more effective at treating the biofilm phenotype of P. aeruginosa strains compared to other currently utilized antibiotics in conditions that approximate the CF lung environment.
520 $a Ultimately, results from both scenarios represent useful data that environmental and medical scientists respectively can use in attempts to begin developing more integrative approaches to effective microbial treatment strategies.
590 $a School code: 0003.
650 4 $a Microbiology. $3 182563
650 4 $a Biochemistry. $3 183428
650 4 $a Biology. $3 171887
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690 $a 0306
710 2 $a The University of Akron. $b Integrated Bioscience. $3 630090
773 0 $t Dissertation Abstracts International $g 77-03B(E).
790 $a 0003
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3730050

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