大葉大學圖書館 |

Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
作者:	Ketter, Patrick Morgan.
面頁冊數:	146 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
Contained By:	Dissertation Abstracts International77-01B(E).
標題:	Immunology.
標題:	Microbiology.
標題:	Molecular biology.
ISBN:	9781339034485
摘要、提要註:	Multi-drug resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Gastrointestinal (GI) tract colonization may contribute to emergence of these MDR A. baumannii isolates. Furthermore, while neutrophils are known to be essential for A. baumannii clearance, little else is known about either the protective host immune response to this pathogen, or virulence factors associated with it. In these studies, we set out to determine the host response to virulence factors associated with A. baumannii with the following specific aims: 1) elucidate the role of pentraxin 3 (PTX3) found in neutrophilic granules in A. baumannii sepsis, 2) elucidate the role of SIgA in A. baumannii GI tract colonization, and 3) characterize the interaction between A. baumannii and SIgA. First, utilizing an intraperitoneal sepsis challenge model, we observed that elevated PTX3 production following A. baumannii challenge was associated with increased morbidity and mortality. Next, we observed enhancement of A. baumannii GI tract colonization in the presence of SIgA using an oral GI challenge model. Finally, using RNAseq and in vitro culture, we found that thioredoxin may contribute to GI tract colonization. These studies ultimately lead us to generate a thioredoxin deletion mutant and corresponding complemented strain for use in future studies to further elucidate the role of thioredoxin in A. bauamannii GI tract colonization.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3721725

Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
Ketter, Patrick Morgan.

Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections. - 146 p.

Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.

Thesis (Ph.D.)--The University of Texas at San Antonio, 2015.

Multi-drug resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Gastrointestinal (GI) tract colonization may contribute to emergence of these MDR A. baumannii isolates. Furthermore, while neutrophils are known to be essential for A. baumannii clearance, little else is known about either the protective host immune response to this pathogen, or virulence factors associated with it. In these studies, we set out to determine the host response to virulence factors associated with A. baumannii with the following specific aims: 1) elucidate the role of pentraxin 3 (PTX3) found in neutrophilic granules in A. baumannii sepsis, 2) elucidate the role of SIgA in A. baumannii GI tract colonization, and 3) characterize the interaction between A. baumannii and SIgA. First, utilizing an intraperitoneal sepsis challenge model, we observed that elevated PTX3 production following A. baumannii challenge was associated with increased morbidity and mortality. Next, we observed enhancement of A. baumannii GI tract colonization in the presence of SIgA using an oral GI challenge model. Finally, using RNAseq and in vitro culture, we found that thioredoxin may contribute to GI tract colonization. These studies ultimately lead us to generate a thioredoxin deletion mutant and corresponding complemented strain for use in future studies to further elucidate the role of thioredoxin in A. bauamannii GI tract colonization.

ISBN: 9781339034485Subjects--Topical Terms:

402223
Immunology.

Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
LDR:02461nam a2200289 4500 001 441002
005 20160422125045.5
008 160525s2015 ||||||||||||||||| ||eng d
020 $a 9781339034485
035 $a (MiAaPQ)AAI3721725
035 $a AAI3721725
040 $a MiAaPQ $c MiAaPQ
100 1 $a Ketter, Patrick Morgan. $3 630067
245 1 0 $a Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
500 $a Adviser: Bernard Arulanandam.
502 $a Thesis (Ph.D.)--The University of Texas at San Antonio, 2015.
520 $a Multi-drug resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Gastrointestinal (GI) tract colonization may contribute to emergence of these MDR A. baumannii isolates. Furthermore, while neutrophils are known to be essential for A. baumannii clearance, little else is known about either the protective host immune response to this pathogen, or virulence factors associated with it. In these studies, we set out to determine the host response to virulence factors associated with A. baumannii with the following specific aims: 1) elucidate the role of pentraxin 3 (PTX3) found in neutrophilic granules in A. baumannii sepsis, 2) elucidate the role of SIgA in A. baumannii GI tract colonization, and 3) characterize the interaction between A. baumannii and SIgA. First, utilizing an intraperitoneal sepsis challenge model, we observed that elevated PTX3 production following A. baumannii challenge was associated with increased morbidity and mortality. Next, we observed enhancement of A. baumannii GI tract colonization in the presence of SIgA using an oral GI challenge model. Finally, using RNAseq and in vitro culture, we found that thioredoxin may contribute to GI tract colonization. These studies ultimately lead us to generate a thioredoxin deletion mutant and corresponding complemented strain for use in future studies to further elucidate the role of thioredoxin in A. bauamannii GI tract colonization.
590 $a School code: 1283.
650 4 $a Immunology. $3 402223
650 4 $a Microbiology. $3 182563
650 4 $a Molecular biology. $3 182854
690 $a 0982
690 $a 0410
690 $a 0307
710 2 $a The University of Texas at San Antonio. $b Biology. $3 630068
773 0 $t Dissertation Abstracts International $g 77-01B(E).
790 $a 1283
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3721725