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Aspergillosis in the fruit fly Droso...

Ramirez Camejo, Luis Alberto.

Aspergillosis in the fruit fly Drosophila melanogaster as a model system.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	Aspergillosis in the fruit fly Drosophila melanogaster as a model system.
作者:	Ramirez Camejo, Luis Alberto.
面頁冊數:	126 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
Contained By:	Dissertation Abstracts International76-10B(E).
標題:	Biology.
標題:	Animal diseases.
標題:	Bioinformatics.
ISBN:	9781321778090
摘要、提要註:	Aspergillus flavus is one of the most important pathogenic fungi, responsible for about 30% of all aspergillosis cases in humans. Currently Drosophila melanogaster has emerged as a powerful alternative for aspergillosis studies.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3705038

Aspergillosis in the fruit fly Drosophila melanogaster as a model system.
Ramirez Camejo, Luis Alberto.

Aspergillosis in the fruit fly Drosophila melanogaster as a model system. - 126 p.

Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.

Thesis (Ph.D.)--University of Puerto Rico, Rio Piedras (Puerto Rico), 2015.

Aspergillus flavus is one of the most important pathogenic fungi, responsible for about 30% of all aspergillosis cases in humans. Currently Drosophila melanogaster has emerged as a powerful alternative for aspergillosis studies.

ISBN: 9781321778090Subjects--Topical Terms:

171887
Biology.

Aspergillosis in the fruit fly Drosophila melanogaster as a model system.
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100 1 $a Ramirez Camejo, Luis Alberto. $3 630029
245 1 0 $a Aspergillosis in the fruit fly Drosophila melanogaster as a model system.
300 $a 126 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
500 $a Adviser: Paul Bayman.
502 $a Thesis (Ph.D.)--University of Puerto Rico, Rio Piedras (Puerto Rico), 2015.
520 $a Aspergillus flavus is one of the most important pathogenic fungi, responsible for about 30% of all aspergillosis cases in humans. Currently Drosophila melanogaster has emerged as a powerful alternative for aspergillosis studies.
520 $a Even though aspergillosis is well-characterized, issues regarding the virulence of A. flavus, defense gene in flies expressed against A. flavus, and the diversity of microorganisms in wild Drosophila with potential use as probiotics against aspergillosis are not well understood.
520 $a The main objective of this first chapter is to provide a brief background to put the following chapters in context. The second chapter is to study induced aspergillosis in flies to determine the virulence of A. flavus strains. Virulence of A. flavus was very variable, ranging from 15% to >90%. Clinical strains were significantly less virulent than environmental strains.
520 $a In the third chapter, I identify genes related to immune defense in flies that may help to provide insight into factors that lead to human aspergillosis. 1,081 of the 14,554 gene regions detected in flies not infected and infected with A. flavus strains of different virulence levels were significantly and differentially expressed. Some of these up/down-regulated genes were previously shown to be involved in defense responses against different pathogens.
520 $a In the fourth chapter I isolate microorganisms from wild Drosophila to elucidate diversity and richness as well as potential humans pathogens. 9 morphospecies of fungi and 12 morphospecies of bacteria were isolated from wild flies. The most abundant were the yeast Candida inconspicua and the bacterium Klebsiella sp. Species richness was higher in fungi but diversity was lower than in bacteria. We identified bacterial and fungal human pathogens in flies.
520 $a The fifth chapter uses microbes isolated from wild Drosophila and others as potential probiotics that help protect hosts against aspergillosis disease. Bacillus cereus (ATCC 13061), Issatchenkia hanoiensis and Candida inconspicua decreased mortality of flies infected with A. flavus. Heat-killed microorganisms did not protect flies.
520 $a The sixth chapter is dedicated to general conclusions of all the work described here. Drosophila melanogaster is an attractive model to answer what I proposed in this thesis dissertation.
590 $a School code: 0281.
650 4 $a Biology. $3 171887
650 4 $a Animal diseases. $3 630031
650 4 $a Bioinformatics. $3 184439
690 $a 0306
690 $a 0476
690 $a 0715
710 2 $a University of Puerto Rico, Rio Piedras (Puerto Rico). $b Biology. $3 630030
773 0 $t Dissertation Abstracts International $g 76-10B(E).
790 $a 0281
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3705038

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