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The effect of antibiotics on Pseudom...

Eastern Kentucky University.

The effect of antibiotics on Pseudomonas aeruginosa biofilm production.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	The effect of antibiotics on Pseudomonas aeruginosa biofilm production.
作者:	Turpin, Courtney.
面頁冊數:	264 p.
附註:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
標題:	Microbiology.
標題:	Molecular biology.
標題:	Biology.
ISBN:	9781339053653
摘要、提要註:	Antibiotic-resistant bacteria have become an increasing burden worldwide. A highly resistant species is Pseudomonas aeruginosa , a nosocomial pathogen that produces a biofilm that enhances its resistance. This project examined the possibility of using bacteriocin, an internal protective toxin produced by some species of bacteria, as a potential treatment for resistant bacteria. In this study, standard broad spectrum antibiotics were used to treat P. aeruginosa to prevent biofilm formation. The biofilm was then analyzed to determine if the biofilm is inhibited or facilitated by each treatment. Optimal concentrations of antibiotics were determined to be effective at a concentration of 0.07mg/mL for gentamicin, rifampicin, and polymyxin B. These antibiotics were used to test 48 clinical samples obtained in 2006. Out of the 48 isolates, a Pseudomonas strain of unknown origin was resistant to both gentamicin and rifampicin (p<0.001). Extraction of Colicin V from E. coli and Pyocin S2 from P. aeruginosa was unsuccessful. Nanodrop analysis determined that there was minimal protein in each sample (concentrations between 0.196-3.118mg/mL). In the future, bacteriocin extractions should be successfully performed, and analysis of further biofilm assays will determine the overall benefit of the treatment.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1599158

The effect of antibiotics on Pseudomonas aeruginosa biofilm production.
Turpin, Courtney.

The effect of antibiotics on Pseudomonas aeruginosa biofilm production. - 264 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--Eastern Kentucky University, 2015.

Antibiotic-resistant bacteria have become an increasing burden worldwide. A highly resistant species is Pseudomonas aeruginosa , a nosocomial pathogen that produces a biofilm that enhances its resistance. This project examined the possibility of using bacteriocin, an internal protective toxin produced by some species of bacteria, as a potential treatment for resistant bacteria. In this study, standard broad spectrum antibiotics were used to treat P. aeruginosa to prevent biofilm formation. The biofilm was then analyzed to determine if the biofilm is inhibited or facilitated by each treatment. Optimal concentrations of antibiotics were determined to be effective at a concentration of 0.07mg/mL for gentamicin, rifampicin, and polymyxin B. These antibiotics were used to test 48 clinical samples obtained in 2006. Out of the 48 isolates, a Pseudomonas strain of unknown origin was resistant to both gentamicin and rifampicin (p<0.001). Extraction of Colicin V from E. coli and Pyocin S2 from P. aeruginosa was unsuccessful. Nanodrop analysis determined that there was minimal protein in each sample (concentrations between 0.196-3.118mg/mL). In the future, bacteriocin extractions should be successfully performed, and analysis of further biofilm assays will determine the overall benefit of the treatment.

ISBN: 9781339053653Subjects--Topical Terms:

182563
Microbiology.

The effect of antibiotics on Pseudomonas aeruginosa biofilm production.
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245 1 4 $a The effect of antibiotics on Pseudomonas aeruginosa biofilm production.
300 $a 264 p.
500 $a Source: Masters Abstracts International, Volume: 55-01.
500 $a Adviser: Marcia M. Pierce.
502 $a Thesis (M.S.)--Eastern Kentucky University, 2015.
520 $a Antibiotic-resistant bacteria have become an increasing burden worldwide. A highly resistant species is Pseudomonas aeruginosa , a nosocomial pathogen that produces a biofilm that enhances its resistance. This project examined the possibility of using bacteriocin, an internal protective toxin produced by some species of bacteria, as a potential treatment for resistant bacteria. In this study, standard broad spectrum antibiotics were used to treat P. aeruginosa to prevent biofilm formation. The biofilm was then analyzed to determine if the biofilm is inhibited or facilitated by each treatment. Optimal concentrations of antibiotics were determined to be effective at a concentration of 0.07mg/mL for gentamicin, rifampicin, and polymyxin B. These antibiotics were used to test 48 clinical samples obtained in 2006. Out of the 48 isolates, a Pseudomonas strain of unknown origin was resistant to both gentamicin and rifampicin (p<0.001). Extraction of Colicin V from E. coli and Pyocin S2 from P. aeruginosa was unsuccessful. Nanodrop analysis determined that there was minimal protein in each sample (concentrations between 0.196-3.118mg/mL). In the future, bacteriocin extractions should be successfully performed, and analysis of further biofilm assays will determine the overall benefit of the treatment.
590 $a School code: 1576.
650 4 $a Microbiology. $3 182563
650 4 $a Molecular biology. $3 182854
650 4 $a Biology. $3 171887
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710 2 $a Eastern Kentucky University. $b Department of Biological Sciences. $3 629913
773 0 $t Masters Abstracts International $g 55-01(E).
790 $a 1576
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1599158

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