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Small molecule inhibition of trans-t...

Huang, Yueyang.

Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability.
作者:	Huang, Yueyang.
面頁冊數:	52 p.
附註:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
標題:	Microbiology.
ISBN:	9781321995893
摘要、提要註:	Staphylococcus aureus quickly develops resistance to antibiotics and poses a significant health threat to humans. New antibiotic targets are needed for the development of new antibiotics. Trans-translation has important roles in maintaining bacterial viability. Small molecules, KKL-35 and KKL-40, were recently identified as specific inhibitors of trans -translation. We have investigated the roles of trans-translation on S. aureus viability and the potential of KKL-35 and KKL-40 as antibiotics. We find that KKLs show bactericidal activity against multiple S. aureus strains at relatively low concentration. We also find that sub-lethal doses of KKLs make S. aureus more susceptible to antimicrobials. Neither KKL-35 nor KKL-40 are cytotoxic to human HeLa cells. Unfortunately, KKL-40 is inactivated by human serum. Therefore, new inhibitors will need to be identified in future studies. Notably, the development of resistance by S.aureus against KKLs remains at a low level. Therefore trans-translation is a promising target for antibiotic development.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1597088

Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability.
Huang, Yueyang.

Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability. - 52 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--Texas Christian University, 2015.

Staphylococcus aureus quickly develops resistance to antibiotics and poses a significant health threat to humans. New antibiotic targets are needed for the development of new antibiotics. Trans-translation has important roles in maintaining bacterial viability. Small molecules, KKL-35 and KKL-40, were recently identified as specific inhibitors of trans -translation. We have investigated the roles of trans-translation on S. aureus viability and the potential of KKL-35 and KKL-40 as antibiotics. We find that KKLs show bactericidal activity against multiple S. aureus strains at relatively low concentration. We also find that sub-lethal doses of KKLs make S. aureus more susceptible to antimicrobials. Neither KKL-35 nor KKL-40 are cytotoxic to human HeLa cells. Unfortunately, KKL-40 is inactivated by human serum. Therefore, new inhibitors will need to be identified in future studies. Notably, the development of resistance by S.aureus against KKLs remains at a low level. Therefore trans-translation is a promising target for antibiotic development.

ISBN: 9781321995893Subjects--Topical Terms:

182563
Microbiology.

Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability.
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020 $a 9781321995893
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100 1 $a Huang, Yueyang. $3 629896
245 1 0 $a Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability.
300 $a 52 p.
500 $a Source: Masters Abstracts International, Volume: 55-01.
500 $a Adviser: Shauna M. Mcgillivray.
502 $a Thesis (M.S.)--Texas Christian University, 2015.
520 $a Staphylococcus aureus quickly develops resistance to antibiotics and poses a significant health threat to humans. New antibiotic targets are needed for the development of new antibiotics. Trans-translation has important roles in maintaining bacterial viability. Small molecules, KKL-35 and KKL-40, were recently identified as specific inhibitors of trans -translation. We have investigated the roles of trans-translation on S. aureus viability and the potential of KKL-35 and KKL-40 as antibiotics. We find that KKLs show bactericidal activity against multiple S. aureus strains at relatively low concentration. We also find that sub-lethal doses of KKLs make S. aureus more susceptible to antimicrobials. Neither KKL-35 nor KKL-40 are cytotoxic to human HeLa cells. Unfortunately, KKL-40 is inactivated by human serum. Therefore, new inhibitors will need to be identified in future studies. Notably, the development of resistance by S.aureus against KKLs remains at a low level. Therefore trans-translation is a promising target for antibiotic development.
590 $a School code: 0229.
650 4 $a Microbiology. $3 182563
690 $a 0410
710 2 $a Texas Christian University. $b College of Science and Engineering. $3 629897
773 0 $t Masters Abstracts International $g 55-01(E).
790 $a 0229
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1597088

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