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Early effects of Staphylococcus aure...

Tankersley, Amy.

Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
書名/作者:	Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes.
作者:	Tankersley, Amy.
面頁冊數:	42 p.
附註:	Source: Masters Abstracts International, Volume: 54-05.
Contained By:	Masters Abstracts International54-05(E).
標題:	Microbiology.
標題:	Immunology.
標題:	Biology.
ISBN:	9781321778243
摘要、提要註:	Chronic wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers are a leading contributor toward mortality throughout the world. The inability of these wounds to heal is associated with the presence of microbial biofilms. The objective of this study was to determine if products secreted by Staphylococcus aureus (S. aureus) biofilms play an active role in chronic wounds by promoting inflammation, which is a hallmark of chronic wounds.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1589711

Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes.
Tankersley, Amy.

Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes. - 42 p.

Source: Masters Abstracts International, Volume: 54-05.

Thesis (M.S.)--University of Central Oklahoma, 2015.

Chronic wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers are a leading contributor toward mortality throughout the world. The inability of these wounds to heal is associated with the presence of microbial biofilms. The objective of this study was to determine if products secreted by Staphylococcus aureus (S. aureus) biofilms play an active role in chronic wounds by promoting inflammation, which is a hallmark of chronic wounds.

ISBN: 9781321778243Subjects--Topical Terms:

182563
Microbiology.

Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes.
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100 1 $a Tankersley, Amy. $3 629835
245 1 0 $a Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes.
300 $a 42 p.
500 $a Source: Masters Abstracts International, Volume: 54-05.
500 $a Adviser: Robert Brennan.
502 $a Thesis (M.S.)--University of Central Oklahoma, 2015.
520 $a Chronic wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers are a leading contributor toward mortality throughout the world. The inability of these wounds to heal is associated with the presence of microbial biofilms. The objective of this study was to determine if products secreted by Staphylococcus aureus (S. aureus) biofilms play an active role in chronic wounds by promoting inflammation, which is a hallmark of chronic wounds.
520 $a In vitro experiments were conducted to examine changes in gene expression profiles and inflammatory response of human epithelial keratinocytes (HEKa) exposed to products secreted by S. aureus grown in biofilms or products secreted by S. aureus grown planktonically.
520 $a After only hours of exposure, gene expression microarray data showed marked differences in inflammatory, apoptotic, and nitric oxide responses between HEKa cells exposed to S. aureus biofilm conditioned media (BCM) and HEKa cells exposed to S. aureus planktonic conditioned media (PCM). As early as 4 hours post exposure, enzyme linked immonosorbant assay (ELISA) results showed significant increases in interleukin 6 (IL-6),interleukin 8 (IL-8), tumor necrosis factor alpha (TNF&agr;), and chemokine ligand 2 (CXCL2) production by HEKa cells exposed to BCM compared to HEKa cells exposed to PCM or controls. Nitric oxide assay data also showed significant increases in nitric oxide production by HEKa cells treated with BCM compared to HEKa cells treated with PCM, or controls. These results support and extend previous findings that indicate products secreted by S. aureus biofilms directly contribute to the chronic inflammation associated with chronic wounds.
590 $a School code: 0503.
650 4 $a Microbiology. $3 182563
650 4 $a Immunology. $3 402223
650 4 $a Biology. $3 171887
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690 $a 0982
690 $a 0306
710 2 $a University of Central Oklahoma. $b Biology. $3 629836
773 0 $t Masters Abstracts International $g 54-05(E).
790 $a 0503
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1589711

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