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Mutant p53 and MDM2 in cancer /

Deb, Sumitra.

Mutant p53 and MDM2 in cancer /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.99/4
書名/作者:	Mutant p53 and MDM2 in cancer // Swati Palit Deb, Sumitra Deb, editors.
其他作者:	Deb, Swati Palit.
出版者:	Dordrecht, [Netherlands] : : Springer,, c2014.
面頁冊數:	viii, 373 p. : : ill. (chiefly col.) ;; 24 cm.
標題:	Cancer - Molecular aspects.
標題:	Cancer - Genetic aspects.
標題:	p53 antioncogene.
ISBN:	9789401792103 (hbk.) :
ISBN:	9401792100 (hbk.)
書目註:	Includes bibliographical references and index.
內容註:	p53 and hereditary cancer -- Alterations of p63 and p73 in human cancers -- Cooperation of p53 mutations with other oncogenic alterations in cancer -- p53: its mutations and their impact on transcription -- Transcriptional regulation by mutant p53 and oncogenesis -- p53 mutation in the genesis of metastasis -- Structural studies on mechanisms to activate mutant p53 -- Mutant p53 and the response to chemotherapy and radiation -- The p53-Mdm2 loop: a critical juncture of stress response -- Mechansims of mutant p53 stabilization in cancer -- Crosstalk between Mdm2, p53 and HIF1-a: distinct responses to oxygen stress and implications for tumour hypoxia -- MDM2 overexpression, activation of signaling networks, and cell proliferation -- p53-independent effecs of Mdm2 -- Splice variants of MDM2 in oncogenesis -- Mdm2 and MdmX involvement in human cancer -- Targeting p53-MDM2-MDMX loop for cancer therapy -- Involvement of p53 in the repair of DNA double strand breaks: multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ) --- The role of tumour suppressor p53 in the antioxidant defense and metabolism -- Lung cancer stem cells, p53 mutations and MDM2.

Mutant p53 and MDM2 in cancer /
Mutant p53 and MDM2 in cancer /Swati Palit Deb, Sumitra Deb, editors. - Dordrecht, [Netherlands] :Springer,c2014. - viii, 373 p. :ill. (chiefly col.) ;24 cm. - Subcellular biochemistry,v. 850306-0225 ;. - Sub-cellular biochemistry ;v. 85..

Includes bibliographical references and index.

p53 and hereditary cancer -- Alterations of p63 and p73 in human cancers -- Cooperation of p53 mutations with other oncogenic alterations in cancer -- p53: its mutations and their impact on transcription -- Transcriptional regulation by mutant p53 and oncogenesis -- p53 mutation in the genesis of metastasis -- Structural studies on mechanisms to activate mutant p53 -- Mutant p53 and the response to chemotherapy and radiation -- The p53-Mdm2 loop: a critical juncture of stress response -- Mechansims of mutant p53 stabilization in cancer -- Crosstalk between Mdm2, p53 and HIF1-a: distinct responses to oxygen stress and implications for tumour hypoxia -- MDM2 overexpression, activation of signaling networks, and cell proliferation -- p53-independent effecs of Mdm2 -- Splice variants of MDM2 in oncogenesis -- Mdm2 and MdmX involvement in human cancer -- Targeting p53-MDM2-MDMX loop for cancer therapy -- Involvement of p53 in the repair of DNA double strand breaks: multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ) --- The role of tumour suppressor p53 in the antioxidant defense and metabolism -- Lung cancer stem cells, p53 mutations and MDM2.

ISBN: 9789401792103 (hbk.) :NTD 5,320

Nat. Bib. No.: GBB4A0396bnb

Nat. Bib. Agency Control No.: 016868864UkSubjects--Topical Terms:

336981
Cancer
--Molecular aspects.

LC Class. No.: RC268.44.P16

Dewey Class. No.: 616.99/4

Mutant p53 and MDM2 in cancer /
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