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Neurobiology of Huntington's disease[electronic resource] :applications to drug discovery /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.851
書名/作者:	Neurobiology of Huntington's disease : applications to drug discovery // edited by Donald C. Lo and Robert E. Hughes.
其他作者:	Lo, Donald C.
出版者:	Boca Raton : : CRC Press/Taylor & Francis Group,, 2010.
面頁冊數:	1 online resource : : ill. (some col.).
標題:	Huntington's chorea - Pathophysiology.
標題:	Huntington's chorea - Molecular aspects.
標題:	Neuropharmacology.
標題:	Huntington Disease - physiopathology.
標題:	Drug Discovery - methods.
標題:	Huntington Disease - drug therapy.
ISBN:	9781420008258 (e-book : PDF)
ISBN:	1420008250 (e-book : PDF)
書目註:	Includes bibliographical references.
摘要、提要註:	"Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description.
電子資源:	http://www.crcnetbase.com/isbn/978-0-8493-9000-5

Neurobiology of Huntington's disease[electronic resource] :applications to drug discovery /
Neurobiology of Huntington's diseaseapplications to drug discovery /[electronic resource] :edited by Donald C. Lo and Robert E. Hughes. - Boca Raton :CRC Press/Taylor & Francis Group,2010. - 1 online resource :ill. (some col.). - Frontiers in neuroscience. - Frontiers in neuroscience (Boca Raton, Fla.).

Includes bibliographical references.

"Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description.

ISBN: 9781420008258 (e-book : PDF)Subjects--Topical Terms:

557816
Huntington's chorea
--Pathophysiology.Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: RC394.H85 / N48 2010

Dewey Class. No.: 616.851 / N494

National Library of Medicine Call No.: WL 390

Neurobiology of Huntington's disease[electronic resource] :applications to drug discovery /
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020 $a 1420008250 (e-book : PDF)
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245 0 0 $a Neurobiology of Huntington's disease $h [electronic resource] : $b applications to drug discovery / $c edited by Donald C. Lo and Robert E. Hughes.
260 $a Boca Raton : $b CRC Press/Taylor & Francis Group, $c 2010.
300 $a 1 online resource : $b ill. (some col.).
490 1 $a Frontiers in neuroscience
504 $a Includes bibliographical references.
520 $a "Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description.
588 $a Description based on print version record.
650 0 $a Huntington's chorea $x Pathophysiology. $3 557816
650 0 $a Huntington's chorea $x Molecular aspects. $3 557817
650 0 $a Neuropharmacology. $3 494014
650 1 2 $a Huntington Disease $x physiopathology. $3 557818
650 2 2 $a Drug Discovery $x methods. $3 438290
650 2 2 $a Huntington Disease $x drug therapy. $3 557819
655 4 $a Electronic books. $2 local $3 336502
700 1 $a Lo, Donald C. $3 557814
700 1 $a Hughes, Robert E., $c Ph.D. $3 557815
830 0 $a Frontiers in neuroscience (Boca Raton, Fla.) $3 487743
856 4 0 $u http://www.crcnetbase.com/isbn/978-0-8493-9000-5