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Models of protection against HIV/SIV[electronic resource] :avoiding AIDS in humans and monkeys /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.979205
書名/作者:	Models of protection against HIV/SIV : avoiding AIDS in humans and monkeys // edited by Gianfranco Pancino, Guido Silvestri, Keith Fowke.
其他作者:	Pancino, Gianfranco.
出版者:	London ; : Academic Press,, 2012.
面頁冊數:	1 online resource (xiv, 345 p.)
標題:	HIV Infections - immunology.
標題:	HIV Infections - prevention & control.
標題:	Disease Models, Animal.
標題:	HIV - immunology.
標題:	Simian Acquired Immunodeficiency Syndrome - immunology.
標題:	HIV infections - Prevention.
標題:	Vaccines - Testing.
ISBN:	9780123877154 (electronic bk.)
ISBN:	0123877156 (electronic bk.)
內容註:	Simian models of non-pathogenic -- SIV infection -- Natural SIV infection: virological aspects -- Natural SIV infection: immunological aspects -- Prevention Implications for therapy HIV-1-exposed seronegative individuals -- Are some people protected against HIV infection? -- The genital mucosa, the front lines in the defense against HIV -- Host genetics and resistance to HIV-1 infection -- The immune system and resisting HIV infection -- HIV-1-controllers -- Definition, natural history and heterogeneity of HIV-controllers -- Residual viremia and viral reservoirs in elite controllers Immune responses associated to viral control Immune mechanisms of viral control in HIV-2 infection -- Genetic basis of protection against HIV -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease.
摘要、提要註:	A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barř-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field.
電子資源:	An electronic book accessible through the World Wide Web; click for information

Models of protection against HIV/SIV[electronic resource] :avoiding AIDS in humans and monkeys /
Models of protection against HIV/SIVavoiding AIDS in humans and monkeys /[electronic resource] :edited by Gianfranco Pancino, Guido Silvestri, Keith Fowke. - 1st ed. - London ;Academic Press,2012. - 1 online resource (xiv, 345 p.)

Simian models of non-pathogenic -- SIV infection -- Natural SIV infection: virological aspects -- Natural SIV infection: immunological aspects -- Prevention Implications for therapy HIV-1-exposed seronegative individuals -- Are some people protected against HIV infection? -- The genital mucosa, the front lines in the defense against HIV -- Host genetics and resistance to HIV-1 infection -- The immune system and resisting HIV infection -- HIV-1-controllers -- Definition, natural history and heterogeneity of HIV-controllers -- Residual viremia and viral reservoirs in elite controllers Immune responses associated to viral control Immune mechanisms of viral control in HIV-2 infection -- Genetic basis of protection against HIV -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease.

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barř-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field.

ISBN: 9780123877154 (electronic bk.)

Source: 1103697:10970221Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

494007
HIV Infections
--immunology.Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: RA644.A25 / M63 2012eb

Dewey Class. No.: 616.979205

National Library of Medicine Call No.: WC 503

Models of protection against HIV/SIV[electronic resource] :avoiding AIDS in humans and monkeys /
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300 $a 1 online resource (xiv, 345 p.)
505 0 $a Simian models of non-pathogenic -- SIV infection -- Natural SIV infection: virological aspects -- Natural SIV infection: immunological aspects -- Prevention Implications for therapy HIV-1-exposed seronegative individuals -- Are some people protected against HIV infection? -- The genital mucosa, the front lines in the defense against HIV -- Host genetics and resistance to HIV-1 infection -- The immune system and resisting HIV infection -- HIV-1-controllers -- Definition, natural history and heterogeneity of HIV-controllers -- Residual viremia and viral reservoirs in elite controllers Immune responses associated to viral control Immune mechanisms of viral control in HIV-2 infection -- Genetic basis of protection against HIV -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease.
520 $a A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barř-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field.
588 $a Description based on print version record.
650 1 2 $a HIV Infections $x immunology. $3 494007
650 1 2 $a HIV Infections $x prevention & control. $3 341955
650 2 2 $a Disease Models, Animal. $3 431442
650 2 2 $a HIV $x immunology. $3 494008
650 2 2 $a Simian Acquired Immunodeficiency Syndrome $x immunology. $3 494009
650 0 $a HIV infections $x Prevention. $3 440835
650 0 $a Vaccines $x Testing. $3 494010
655 4 $a Electronic books. $2 local $3 336502
700 1 $a Pancino, Gianfranco. $3 494004
700 1 $a Silvestri, Guido, $c MD. $3 494005
700 1 $a Fowke, Keith R. $3 494006
710 2 $a ScienceDirect (Online service) $3 365609
776 0 8 $i Print version: $t Models of protection against HIV/SIV. $d Oxford : Academic, 2012 $z 9780123877154 $w (OCoLC)755071538
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123877154 $z An electronic book accessible through the World Wide Web; click for information