大葉大學圖書館 |

Clinical trials in the neurosciences[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.80072/4
書名/作者:	Clinical trials in the neurosciences/ volume editors, K.M. Woodbury-Harris, B.M. Coull.
其他作者:	Woodbury-Harris, K. M.
出版者:	Basel : : S. Karger,, 2009
面頁冊數:	1 online resource : : ill. (some col.)
附註:	A comprehensive and practical overview
標題:	Neurology - Research.
標題:	Neurosciences - Research.
標題:	Clinical trials.
標題:	Clinical Trials as Topic.
標題:	Neurology - methods.
標題:	Nervous System Diseases.
標題:	Neurosurgical Procedures.
標題:	Research Design.
ISBN:	9783805590242
書目註:	Includes bibliographical references and indexes.
摘要、提要註:	A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed.This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.
電子資源:	http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&searchWhat=books&searchParm=toc&ProduktNr=242160

Clinical trials in the neurosciences[electronic resource] /
Clinical trials in the neurosciences[electronic resource] /volume editors, K.M. Woodbury-Harris, B.M. Coull. - Basel :S. Karger,2009 - 1 online resource :ill. (some col.) - Frontiers of Neurology and Neuroscience,v.251662-2804 ;. - Frontiers of neurology and neuroscience ;v.25..

A comprehensive and practical overview

Includes bibliographical references and indexes.

A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed.This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.

ISBN: 9783805590242Subjects--Topical Terms:

431001
Neurology
--Research.

LC Class. No.: RC337 / .C63 2009

Dewey Class. No.: 616.80072/4

National Library of Medicine Call No.: W1 / MO568C v.25 2009

Clinical trials in the neurosciences[electronic resource] /
LDR:02319cam a2200265 a 4500 001 350392
003 SZ-BaSKA
005 20110603112133.0
006 m d
007 cr cnu---unuuu
008 111219s2009 sz a ob 001 0 eng d
020 $a 9783805590242
035 $a 242160
040 $a szbaska
050 0 0 $a RC337 $b .C63 2009
060 0 0 $a W1 $b MO568C v.25 2009
060 1 0 $a WL 100 $b C6439 2009
082 0 0 $a 616.80072/4 $2 22
245 0 0 $a Clinical trials in the neurosciences $h [electronic resource] / $c volume editors, K.M. Woodbury-Harris, B.M. Coull.
260 $a Basel : $b S. Karger, $c 2009
300 $a 1 online resource : $b ill. (some col.)
490 1 $a Frontiers of Neurology and Neuroscience, $x 1662-2804 ; $v v.25
500 $a A comprehensive and practical overview
504 $a Includes bibliographical references and indexes.
520 $a A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed.This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.
650 0 $a Neurology $x Research. $3 431001
650 0 $a Neurosciences $x Research. $3 438607
650 0 $a Clinical trials. $3 339385
650 1 2 $a Clinical Trials as Topic. $3 438608
650 1 2 $a Neurology $x methods. $3 438609
650 2 2 $a Nervous System Diseases. $3 401900
650 2 2 $a Neurosurgical Procedures. $3 428809
650 2 2 $a Research Design. $3 344491
700 1 $a Woodbury-Harris, K. M. $q (Katherine M.) $3 438604
700 1 $a Coull, B. M. $q (Bruce M.) $3 438605
830 0 $a Frontiers of neurology and neuroscience ; $v v.25. $3 438606
856 4 0 $u http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&searchWhat=books&searchParm=toc&ProduktNr=242160