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Drug-like properties[electronic resource] :concepts, structure design and methods : from ADME to toxicity optimization /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	615/.19
書名/作者:	Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization // Edward H. Kerns and Li Di.
作者:	Kerns, Edward Harvel.
其他作者:	Di, Li.
出版者:	Amsterdam ; : Academic Press,, c2008.
面頁冊數:	xix, 526 p., [2] p. of plates : : ill. (some col.) ;; 27 cm.
標題:	Pharmaceutical chemistry.
標題:	Drugs - Structure-activity relationships.
標題:	Drug development.
標題:	Drugs - Design.
標題:	Drug Design.
標題:	Drug Evaluation, Preclinical.
標題:	Drug Toxicity.
標題:	Pharmaceutical Preparations - metabolism.
標題:	Pharmacokinetics.
標題:	Structure-Activity Relationship.
ISBN:	9780123695208
ISBN:	0123695201
書目註:	Includes bibliographical references (p. 492) and index.
內容註:	Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary.
摘要、提要註:	Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint.
電子資源:	An electronic book accessible through the World Wide Web; click for information

Drug-like properties[electronic resource] :concepts, structure design and methods : from ADME to toxicity optimization /
Kerns, Edward Harvel.

Drug-like propertiesconcepts, structure design and methods : from ADME to toxicity optimization /[electronic resource] :Edward H. Kerns and Li Di. - Amsterdam ;Academic Press,c2008. - xix, 526 p., [2] p. of plates :ill. (some col.) ;27 cm.

Includes bibliographical references (p. 492) and index.

Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary.

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780123695208

Source: 130415:130518Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

223006
Pharmaceutical chemistry.
Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: RS420 / .K47 2008eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: 2008 D-072

Drug-like properties[electronic resource] :concepts, structure design and methods : from ADME to toxicity optimization /
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