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Molecular biology of B cells[electronic resource] /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	616.07/98
書名/作者:	Molecular biology of B cells/ edited by Tasuku Honjo, Frederick W. Alt, Michael S. Neuberger.
其他作者:	Honjo, T.
出版者:	Amsterdam ; : Elsevier,, 2004.
面頁冊數:	xiv, 589 p. : : col. ill. ;; 29 cm.
標題:	Molecular immunology.
標題:	B cells.
標題:	Immunoglobulins.
標題:	Immunoglobulin genes.
標題:	B-Lymphocytes - immunology.
標題:	Genes, Immunoglobulin.
標題:	Genetic Processes.
標題:	Linf�ocitos b.
標題:	Imunologia celular.
標題:	Imunoglobulinas.
標題:	Biologia molecular.
標題:	Immunologie mol�eculaire.
標題:	Lymphocytes B.
標題:	Immunoglobulines.
標題:	G�enes de l'immunoglobuline.
ISBN:	9780120536412
ISBN:	0120536412
書目註:	Includes bibliographical references and index.
內容註:	ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES -- Human Immunoglobulin heavy chains locus -- Immunoglobulin heavy chain genes of mouse -- Immunoglobulin? genes of human and mouse -- Immunoglobulin lambdav (IGL) genes of human and mouse -- The Mechanism of V(D) J Recombination -- Transcription of Immunoglobulin genes -- B CELLS AND THEIR DEVELOPMENT -- Early B cell development to a mature, antigen-sensitive cell -- cellular stages and molecular decisions -- Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination -- The Development of Human B Lymphocytes -- Development and function of B cell subsets -- B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION -- Structure and function of B cells antigen receptor complexes -- Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22 -- The dynamic structure of antibody responses -- Dynamics of B cell migration to and within secondary lymphoid organs -- Characteristics of mucosal B cells with emphasis on the human secretory immune system -- The Cellular Basis of B Cell Memory -- Immunoglobulin assembly and secretion -- Fc And Complement Receptors -- Ig GENE ALTERATION IN PERIPHERY -- Regulation of Class Switch Recombination -- Molecular Mechanism of Class Switch Recombination -- Molecular Mechanism of Hypermutation -- Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody -- DISEASES OF B CELLS -- Chromosomal Translocations in B-cell Leukemias and Lymphomas -- Classification and Characteristics of Mouse B Cell-Lineage Lymphomas -- B cells producing pathogenic autoantibodies -- Immunodeficiencies Caused by B Cell Defects -- EVOLUTION OF Ig GENES -- Diverse forms of Immunoglobulin Genes in Lower Vertebrates -- Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT -- The zebrafish immune system -- The Origin of V(D)J Diversification -- FUNCTION AND APPLICATION OF IMMUNOGLOBULINS -- Antibody Structure and Recognition of Antigen -- Monoclonal antibodies from display libraries -- Humanization of Monoclonal Antibodies -- Human monoclonal antibodies from translocus mice.
摘要、提要註:	Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
電子資源:	An electronic book accessible through the World Wide Web; click for information

Molecular biology of B cells[electronic resource] /
Molecular biology of B cells[electronic resource] /edited by Tasuku Honjo, Frederick W. Alt, Michael S. Neuberger. - Amsterdam ;Elsevier,2004. - xiv, 589 p. :col. ill. ;29 cm.

Includes bibliographical references and index.

ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES -- Human Immunoglobulin heavy chains locus -- Immunoglobulin heavy chain genes of mouse -- Immunoglobulin? genes of human and mouse -- Immunoglobulin lambdav (IGL) genes of human and mouse -- The Mechanism of V(D) J Recombination -- Transcription of Immunoglobulin genes -- B CELLS AND THEIR DEVELOPMENT -- Early B cell development to a mature, antigen-sensitive cell -- cellular stages and molecular decisions -- Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination -- The Development of Human B Lymphocytes -- Development and function of B cell subsets -- B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION -- Structure and function of B cells antigen receptor complexes -- Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22 -- The dynamic structure of antibody responses -- Dynamics of B cell migration to and within secondary lymphoid organs -- Characteristics of mucosal B cells with emphasis on the human secretory immune system -- The Cellular Basis of B Cell Memory -- Immunoglobulin assembly and secretion -- Fc And Complement Receptors -- Ig GENE ALTERATION IN PERIPHERY -- Regulation of Class Switch Recombination -- Molecular Mechanism of Class Switch Recombination -- Molecular Mechanism of Hypermutation -- Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody -- DISEASES OF B CELLS -- Chromosomal Translocations in B-cell Leukemias and Lymphomas -- Classification and Characteristics of Mouse B Cell-Lineage Lymphomas -- B cells producing pathogenic autoantibodies -- Immunodeficiencies Caused by B Cell Defects -- EVOLUTION OF Ig GENES -- Diverse forms of Immunoglobulin Genes in Lower Vertebrates -- Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT -- The zebrafish immune system -- The Origin of V(D)J Diversification -- FUNCTION AND APPLICATION OF IMMUNOGLOBULINS -- Antibody Structure and Recognition of Antigen -- Monoclonal antibodies from display libraries -- Humanization of Monoclonal Antibodies -- Human monoclonal antibodies from translocus mice.

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780120536412

Source: 97397:97398Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

428435
Molecular immunology.
Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: QR185.6 / .M653 2004eb

Dewey Class. No.: 616.07/98

National Library of Medicine Call No.: 2004 B-470

Molecular biology of B cells[electronic resource] /
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245 0 0 $a Molecular biology of B cells $h [electronic resource] / $c edited by Tasuku Honjo, Frederick W. Alt, Michael S. Neuberger.
260 $a Amsterdam ; $a Boston : $b Elsevier, $c 2004.
300 $a xiv, 589 p. : $b col. ill. ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES -- Human Immunoglobulin heavy chains locus -- Immunoglobulin heavy chain genes of mouse -- Immunoglobulin? genes of human and mouse -- Immunoglobulin lambdav (IGL) genes of human and mouse -- The Mechanism of V(D) J Recombination -- Transcription of Immunoglobulin genes -- B CELLS AND THEIR DEVELOPMENT -- Early B cell development to a mature, antigen-sensitive cell -- cellular stages and molecular decisions -- Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination -- The Development of Human B Lymphocytes -- Development and function of B cell subsets -- B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION -- Structure and function of B cells antigen receptor complexes -- Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22 -- The dynamic structure of antibody responses -- Dynamics of B cell migration to and within secondary lymphoid organs -- Characteristics of mucosal B cells with emphasis on the human secretory immune system -- The Cellular Basis of B Cell Memory -- Immunoglobulin assembly and secretion -- Fc And Complement Receptors -- Ig GENE ALTERATION IN PERIPHERY -- Regulation of Class Switch Recombination -- Molecular Mechanism of Class Switch Recombination -- Molecular Mechanism of Hypermutation -- Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody -- DISEASES OF B CELLS -- Chromosomal Translocations in B-cell Leukemias and Lymphomas -- Classification and Characteristics of Mouse B Cell-Lineage Lymphomas -- B cells producing pathogenic autoantibodies -- Immunodeficiencies Caused by B Cell Defects -- EVOLUTION OF Ig GENES -- Diverse forms of Immunoglobulin Genes in Lower Vertebrates -- Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT -- The zebrafish immune system -- The Origin of V(D)J Diversification -- FUNCTION AND APPLICATION OF IMMUNOGLOBULINS -- Antibody Structure and Recognition of Antigen -- Monoclonal antibodies from display libraries -- Humanization of Monoclonal Antibodies -- Human monoclonal antibodies from translocus mice.
520 $a Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Aug. 2, 2007). $n Access may be restricted to users at subscribing institutions.
650 0 $a Molecular immunology. $3 428435
650 0 $a B cells. $3 428436
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650 0 $a Immunoglobulin genes. $3 428438
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650 2 2 $a Genetic Processes. $3 428441
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650 7 $a Imunologia celular. $2 larpcal $3 428443
650 7 $a Imunoglobulinas. $2 larpcal $3 428444
650 7 $a Biologia molecular. $2 larpcal $3 428445
650 6 $a Immunologie mol�eculaire. $3 428446
650 6 $a Lymphocytes B. $3 428447
650 6 $a Immunoglobulines. $3 428448
650 6 $a G�enes de l'immunoglobuline. $3 428449
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700 1 $a Honjo, T. $q (Tasuku), $d 1942- $3 428432
700 1 $a Alt, Frederick W. $3 428433
700 1 $a Neuberger, M. S. $q (Michael S.) $3 428434
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