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[ author_sort:"ketter, patrick morgan." ]
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Study of virulence factors associate...
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Ketter, Patrick Morgan.
Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
書名/作者:
Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
作者:
Ketter, Patrick Morgan.
面頁冊數:
146 p.
附註:
Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
Contained By:
Dissertation Abstracts International77-01B(E).
標題:
Immunology.
標題:
Microbiology.
標題:
Molecular biology.
ISBN:
9781339034485
摘要、提要註:
Multi-drug resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Gastrointestinal (GI) tract colonization may contribute to emergence of these MDR A. baumannii isolates. Furthermore, while neutrophils are known to be essential for A. baumannii clearance, little else is known about either the protective host immune response to this pathogen, or virulence factors associated with it. In these studies, we set out to determine the host response to virulence factors associated with A. baumannii with the following specific aims: 1) elucidate the role of pentraxin 3 (PTX3) found in neutrophilic granules in A. baumannii sepsis, 2) elucidate the role of SIgA in A. baumannii GI tract colonization, and 3) characterize the interaction between A. baumannii and SIgA. First, utilizing an intraperitoneal sepsis challenge model, we observed that elevated PTX3 production following A. baumannii challenge was associated with increased morbidity and mortality. Next, we observed enhancement of A. baumannii GI tract colonization in the presence of SIgA using an oral GI challenge model. Finally, using RNAseq and in vitro culture, we found that thioredoxin may contribute to GI tract colonization. These studies ultimately lead us to generate a thioredoxin deletion mutant and corresponding complemented strain for use in future studies to further elucidate the role of thioredoxin in A. bauamannii GI tract colonization.
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3721725
Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
Ketter, Patrick Morgan.
Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
- 146 p.
Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
Thesis (Ph.D.)--The University of Texas at San Antonio, 2015.
Multi-drug resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Gastrointestinal (GI) tract colonization may contribute to emergence of these MDR A. baumannii isolates. Furthermore, while neutrophils are known to be essential for A. baumannii clearance, little else is known about either the protective host immune response to this pathogen, or virulence factors associated with it. In these studies, we set out to determine the host response to virulence factors associated with A. baumannii with the following specific aims: 1) elucidate the role of pentraxin 3 (PTX3) found in neutrophilic granules in A. baumannii sepsis, 2) elucidate the role of SIgA in A. baumannii GI tract colonization, and 3) characterize the interaction between A. baumannii and SIgA. First, utilizing an intraperitoneal sepsis challenge model, we observed that elevated PTX3 production following A. baumannii challenge was associated with increased morbidity and mortality. Next, we observed enhancement of A. baumannii GI tract colonization in the presence of SIgA using an oral GI challenge model. Finally, using RNAseq and in vitro culture, we found that thioredoxin may contribute to GI tract colonization. These studies ultimately lead us to generate a thioredoxin deletion mutant and corresponding complemented strain for use in future studies to further elucidate the role of thioredoxin in A. bauamannii GI tract colonization.
ISBN: 9781339034485Subjects--Topical Terms:
402223
Immunology.
Study of virulence factors associated with Acinetobacter baumannii systemic and gastrointestinal infections.
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Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
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Multi-drug resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Gastrointestinal (GI) tract colonization may contribute to emergence of these MDR A. baumannii isolates. Furthermore, while neutrophils are known to be essential for A. baumannii clearance, little else is known about either the protective host immune response to this pathogen, or virulence factors associated with it. In these studies, we set out to determine the host response to virulence factors associated with A. baumannii with the following specific aims: 1) elucidate the role of pentraxin 3 (PTX3) found in neutrophilic granules in A. baumannii sepsis, 2) elucidate the role of SIgA in A. baumannii GI tract colonization, and 3) characterize the interaction between A. baumannii and SIgA. First, utilizing an intraperitoneal sepsis challenge model, we observed that elevated PTX3 production following A. baumannii challenge was associated with increased morbidity and mortality. Next, we observed enhancement of A. baumannii GI tract colonization in the presence of SIgA using an oral GI challenge model. Finally, using RNAseq and in vitro culture, we found that thioredoxin may contribute to GI tract colonization. These studies ultimately lead us to generate a thioredoxin deletion mutant and corresponding complemented strain for use in future studies to further elucidate the role of thioredoxin in A. bauamannii GI tract colonization.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3721725
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