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国際標準書誌記述(ISBD)
Evaluation of enzyme inhibitors in d...
~
Copeland, Robert Allen.
Evaluation of enzyme inhibitors in drug discovery[electronic resource] :a guide for medicinal chemists and pharmacologists /
レコード種別:
言語・文字資料 (印刷物) : 単行資料
[NT 15000414] null:
615/.19
タイトル / 著者:
Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists // Robert A. Copeland.
著者:
Copeland, Robert Allen.
出版された:
Hoboken, N.J. : : Wiley,, c2013.
記述:
1 online resource (xxxi, 538 p.)
主題:
Enzyme inhibitors - Therapeutic use
主題:
Drugs - Design.
主題:
Enzyme inhibitors - Structure-activity relationships.
主題:
Enzyme Inhibitors - therapeutic use.
主題:
Drug Design.
主題:
Enzyme Inhibitors - chemistry.
国際標準図書番号 (ISBN) :
9781118540404 (electronic bk.)
国際標準図書番号 (ISBN) :
1118540409 (electronic bk.)
国際標準図書番号 (ISBN) :
9781118540282 (electronic bk.)
国際標準図書番号 (ISBN) :
111854028X (electronic bk.)
国際標準図書番号 (ISBN) :
9781118540398 (electronic bk.)
国際標準図書番号 (ISBN) :
1118540395 (electronic bk.)
[NT 15000227] null:
Includes bibliographical references and index.
[NT 15000229] null:
"There has been explosive growth in the hunt for new pharmaceutically agents globally. Traditionally, this has been the purview of the pharmaceutical industry, but today, this effort crosses academic, government, and industry laboratories across the world. Enzymes remain the most valued and common of drug targets; hence, a detailed understanding of their interactions with inhibitors is critical to successful drug discovery. This book provides a practical, readable, and comprehensive treatment of these topics that allows scientists to master the art of applied enzymology for drug discovery. The book addresses the opportunities for inhibitor interactions with enzyme targets arising from consideration of the catalytic reaction mechanism; discusses how inhibitors are properly evaluated for potency, selectivity, and mode of action, covers the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo, and provides valuable biochemical insights to help medicinal chemists and pharmacologists most effectively pursue lead optimization. It includes two new chapters, one on the pioneering idea of drug-target residence time fostered by Dr. Copeland, and the second on quantitative biochemistry. Five new appendices are added"--Provided by publisher.
電子資源:
http://onlinelibrary.wiley.com/book/10.1002/9781118540398
Evaluation of enzyme inhibitors in drug discovery[electronic resource] :a guide for medicinal chemists and pharmacologists /
Copeland, Robert Allen.
Evaluation of enzyme inhibitors in drug discovery
a guide for medicinal chemists and pharmacologists /[electronic resource] :Robert A. Copeland. - 2nd ed. - Hoboken, N.J. :Wiley,c2013. - 1 online resource (xxxi, 538 p.)
Includes bibliographical references and index.
"There has been explosive growth in the hunt for new pharmaceutically agents globally. Traditionally, this has been the purview of the pharmaceutical industry, but today, this effort crosses academic, government, and industry laboratories across the world. Enzymes remain the most valued and common of drug targets; hence, a detailed understanding of their interactions with inhibitors is critical to successful drug discovery. This book provides a practical, readable, and comprehensive treatment of these topics that allows scientists to master the art of applied enzymology for drug discovery. The book addresses the opportunities for inhibitor interactions with enzyme targets arising from consideration of the catalytic reaction mechanism; discusses how inhibitors are properly evaluated for potency, selectivity, and mode of action, covers the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo, and provides valuable biochemical insights to help medicinal chemists and pharmacologists most effectively pursue lead optimization. It includes two new chapters, one on the pioneering idea of drug-target residence time fostered by Dr. Copeland, and the second on quantitative biochemistry. Five new appendices are added"--Provided by publisher.
ISBN: 9781118540404 (electronic bk.)
LCCN: 2012046209Subjects--Topical Terms:
588200
Enzyme inhibitors
--Therapeutic use
LC Class. No.: QP601.5 / .C675 2013
Dewey Class. No.: 615/.19
National Library of Medicine Call No.: QU 143
Evaluation of enzyme inhibitors in drug discovery[electronic resource] :a guide for medicinal chemists and pharmacologists /
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a guide for medicinal chemists and pharmacologists /
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Robert A. Copeland.
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http://onlinelibrary.wiley.com/book/10.1002/9781118540398
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http://onlinelibrary.wiley.com/book/10.1002/9781118540398
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