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Drug stereochemistry[electronic resource] :analytical methods and pharmacology /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
杜威分類號:	615/.19
書名/作者:	Drug stereochemistry : analytical methods and pharmacology // [edited by] Krzysztof Jozwiak, W. John Lough, Irving W. Wainer.
其他作者:	Jozwiak, Krzysztof,
出版者:	New York : : Informa Healthcare,, 2012.
面頁冊數:	1 online resource (x, 322 p.) : : ill.
標題:	Chiral drugs.
標題:	Pharmaceutical chemistry.
標題:	Stereochemistry.
標題:	Chemistry, Pharmaceutical - methods.
標題:	Molecular Conformation.
標題:	Stereoisomerism.
ISBN:	9781420092394 (electronic bk.)
ISBN:	1420092391 (electronic bk.)
ISBN:	1420092383
ISBN:	9781420092387
書目註:	Includes bibliographical references and index.
摘要、提要註:	"Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher.
電子資源:	http://informahealthcare.com/isbn/9781420092394

Drug stereochemistry[electronic resource] :analytical methods and pharmacology /
Drug stereochemistryanalytical methods and pharmacology /[electronic resource] :[edited by] Krzysztof Jozwiak, W. John Lough, Irving W. Wainer. - 3rd ed. - New York :Informa Healthcare,2012. - 1 online resource (x, 322 p.) :ill. - Drugs and the pharmaceutical science series ;211. - Drugs and the pharmaceutical sciences ;v. 183-184.

Includes bibliographical references and index.

"Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher.

ISBN: 9781420092394 (electronic bk.)Subjects--Topical Terms:

461364
Chiral drugs.
Index Terms--Genre/Form:

336502
Electronic books.

LC Class. No.: RS429 / .D78 2012eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: QV 744

Drug stereochemistry[electronic resource] :analytical methods and pharmacology /
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245 0 0 $a Drug stereochemistry $h [electronic resource] : $b analytical methods and pharmacology / $c [edited by] Krzysztof Jozwiak, W. John Lough, Irving W. Wainer.
250 $a 3rd ed.
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300 $a 1 online resource (x, 322 p.) : $b ill.
490 1 $a Drugs and the pharmaceutical science series ; $v 211
504 $a Includes bibliographical references and index.
520 $a "Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher.
588 $a Description based on print version record.
650 0 $a Chiral drugs. $3 461364
650 0 $a Pharmaceutical chemistry. $3 223006
650 0 $a Stereochemistry. $3 404126
650 1 2 $a Chemistry, Pharmaceutical $x methods. $3 431435
650 2 2 $a Molecular Conformation. $3 489472
650 2 2 $a Stereoisomerism. $3 489473
655 4 $a Electronic books. $2 local $3 336502
700 1 $a Jozwiak, Krzysztof, $d 1971- $3 489469
700 1 $a Lough, W. J. $q (W. John) $3 489470
700 1 $a Wainer, Irving W. $3 489471
830 0 $a Drugs and the pharmaceutical sciences ; $v v. 183-184 $3 437650
856 4 0 $u http://informahealthcare.com/isbn/9781420092394