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Peptidomimetics in organic and medic...

Guarna, Antonio.

Peptidomimetics in organic and medicinal chemistry[electronic resource] :the art of transforming peptides in drugs /

レコード種別:	言語・文字資料 (印刷物) : 単行資料
[NT 15000414] null:	615.1/9
タイトル / 著者:	Peptidomimetics in organic and medicinal chemistry : the art of transforming peptides in drugs // Andrea Trabocchi and Antonio Guarna.
著者:	Trabocchi, Andrea.
その他の著者:	Guarna, Antonio.
出版された:	Chichester, West Sussex ; : Wiley,, 2014.
記述:	1 online resource. (xix, 288 p.) : : ill.
主題:	Peptide drugs.
主題:	Proteins - Therapeutic use.
主題:	Drugs - Design.
国際標準図書番号 (ISBN) :	9781118683033 (electronic bk.)
国際標準図書番号 (ISBN) :	111868303X (electronic bk.)
国際標準図書番号 (ISBN) :	9781118683842 (electronic bk.)
国際標準図書番号 (ISBN) :	1118683846 (electronic bk.)
[NT 15000227] null:	Includes bibliographical references and index.
[NT 15000229] null:	"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--
電子資源:	http://onlinelibrary.wiley.com/book/10.1002/9781118683033

Peptidomimetics in organic and medicinal chemistry[electronic resource] :the art of transforming peptides in drugs /
Trabocchi, Andrea.

Peptidomimetics in organic and medicinal chemistrythe art of transforming peptides in drugs /[electronic resource] :Andrea Trabocchi and Antonio Guarna. - Chichester, West Sussex ;Wiley,2014. - 1 online resource. (xix, 288 p.) :ill.

Includes bibliographical references and index.

"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--

ISBN: 9781118683033 (electronic bk.)

LCCN: 2013051081Subjects--Topical Terms:

438287
Peptide drugs.

LC Class. No.: RS431.P38

Dewey Class. No.: 615.1/9

Peptidomimetics in organic and medicinal chemistry[electronic resource] :the art of transforming peptides in drugs /
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020 $a 9781118683033 (electronic bk.)
020 $a 111868303X (electronic bk.)
020 $a 9781118683842 (electronic bk.)
020 $a 1118683846 (electronic bk.)
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020 $z 1118683145
020 $z 9781119950608 (hardback)
020 $z 1119950600 (hardback)
035 $a (OCoLC)867001313
035 $a ocn867001313
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050 1 0 $a RS431.P38
082 0 0 $a 615.1/9 $2 23
100 1 $a Trabocchi, Andrea. $3 588248
245 1 0 $a Peptidomimetics in organic and medicinal chemistry $h [electronic resource] : $b the art of transforming peptides in drugs / $c Andrea Trabocchi and Antonio Guarna.
260 $a Chichester, West Sussex ; $a Hoboken, N.J. : $b Wiley, $c 2014.
300 $a 1 online resource. (xix, 288 p.) : $b ill.
504 $a Includes bibliographical references and index.
520 $a "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- $c Provided by publisher.
520 $a "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- $c Provided by publisher.
588 $a Description based on online resource; title from PDF title page (Wiley, viewed April 3, 2014)
650 0 $a Peptide drugs. $3 438287
650 0 $a Proteins $x Therapeutic use. $3 438285
650 0 $a Drugs $x Design. $3 424032
700 1 $a Guarna, Antonio. $3 623763
856 4 0 $u http://onlinelibrary.wiley.com/book/10.1002/9781118683033

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